The impact of HCV eradication using interferon-free direct acting antivirals on bone-mineral, anemia parameters and peripheral insulin resistance in hepatitis c-infected Egyptian hemodialysis cohort

Table 4 Results of multiple regression analyses of HB and HOMA-IR changes after SVR

Coefficients^a
Model	Unstandardized coefficients		Standardized coefficients	t	Sig	95% confidence interval for B
Model	B	Std. Error	Beta	t	Sig	Lower bound	Upper bound
(Constant)	10.459	0.822	–	12.717	0.000	8.841	12.077
Iron (after 6 m)	0.000	0.006	− 0.017	− 0.078	0.938	− 0.011	0.011
TIBC (after 6 m)	0.001	0.003	0.048	0.321	0.748	− 0.004	0.006
TSAT (after 6 m)	0.006	0.016	0.000	− 0.001	0.999	− 0.032	0.032
Ferritin(after 6 m)	0.004	0.002	0.126	2.298	0.022	0.001	0.007

Coefficients^b
Model	Unstandardized coefficients		Standardized coefficients	t	Sig	95% confidence interval for B
Model	B	Std. error	Beta	t	Sig	Lower bound	Upper bound
(Constant)	10.893	1.116	–	9.764	0.000	8.699	13.088
Iron (after 12 m)	− 0.003	0.006	− 0.099	− 0.411	0.681	− 0.015	0.010
TIBC (after 12 m)	0.002	0.003	0.106	0.557	0.578	− 0.005	0.008
TSAT (after 12 m)	0.007	0.020	0.099	0.340	0.734	− 0.032	0.046
Ferritin (after 12 m)	0.002	0.002	0.076	1.380	0.169	− 0 .001	0.005

Coefficients^c
Model	Unstandardized coefficients		Standardized coefficients	t	Sig	95% confidence interval for B
Model	B	Std. error	Beta	t	Sig	Lower bound	Upper bound
(Constant)	− 20.227	0.816	−	− 24.788	0.000	− 21.832	− 18.622
HB	− 0.011	0.020	− 0.031	− 0.557	0.578	− 0.051	0.028
Ferritin	0.000	0.003	0.009	0.161	0.872	− 0.005	0.005
Ca	−0 .020	0.045	− 0.025	− 0.451	0.652	− 0.108	0.068
PO4	− 0.032	0.027	−0 .066	− 1.185	0.237	− 0.086	0.021
PTH	0.014	0.008	0.103	1.876	0.062	− 0.001	0.029

HB = Hemoglobin; Po4 = serum phosphorus; Ca = serum Calcium; PTH = serum parathyroid hormone; FGF23 = Fibroblast growth factor 23; HOMA IR = HOMA insulin resistance, SVR: Sustained virological response
^aDependent Variable: Hb_After_6 month
^bDependent Variable: Hb_After_12 month
^cDependent Variable: HOMA IR percent change

ISSN: 2059-1381