Fig. 2

Clinical course of case 2 after admission to the intensive care unit (ICU). The patient had sepsis, acute kidney injury, and disseminated intravascular coagulation. Intensive therapy improved his general health status. On day 4 after ICU admission, the patient received CHOP therapy. Blood purification was initiated to prevent exacerbation of tumor lysis syndrome (TLS). To maintain the therapeutic blood concentrations of the anticancer agents, we discontinued the use of the sustained high-efficiency daily diafiltration mediator-adsorbing membrane (SHEDD-fA) temporarily before chemotherapy, restarted it 6 h after completion of chemotherapy, and followed it up with continuous hemofiltration (CHF). After chemotherapy, no abnormalities related to TLS were observed. The patient was discharged from the ICU on day 21 after ICU admission