High-dose atorvastatin reduces oxidative stress of ischemia/reperfusion injury after isogeneic kidney transplantation in rats: in vivo, preclinical, case–control, open-label study

Table 1 Effect of High-dose atorvastatin on Glutathione Peroxidase (GPx), Superoxide Dismutase (SOD), Malondialdehyde (MDA) and Myeloperoxidase (MPO) activity on rat groups (A = Transplantation only (control): B = High-dose Atorvastatin + Transplant; C = Left kidney transplant + Right nephrectomy; D = High-dose Atorvastatin + Left kidney transplant + Right nephrectomy)

	GPX (nmoli/min/ml)		SOD (nmoli/min/ml)		MDA (nmoli/min/ml)		MPO (UI/ml)
Comparison between groups	Mean ± SD	P value	Mean ± SD	P value	Mean ± SD	P value	Mean ± SD	P value
A versus B	39.14 ± 27.45	0.001	8.26 ± 3.85	< 0.001	25.21 ± 5.22	0.002	3.14 ± 2.80	0.02
A versus B	80.62 ± 49.11	0.001	13.38 ± 1.33	< 0.001	18.33 ± 6.79	0.002	1.743 ± 040	0.02
C versus D	67.70 ± 49.78	0.28	10.26 ± 3.31	0.011	24.81 ± 6.47	0.11	2.57 ± 0.13	0.027
C versus D	84.63 ± 49.10	0.28	12.55 ± 1.88	0.011	21.96 ± 3.02	0.11	1.67 ± 0.95	0.027

ISSN: 2059-1381