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Fig. 3 | Renal Replacement Therapy

Fig. 3

From: Dyslipidemia in diabetic nephropathy

Fig. 3

Inhibition of Rho/Rho-kinase by statins. The pleiotropic effect of statins is exerted by Rho-kinase inhibition. Statins inhibit the production of isoprenoids, which are important for Rho activation. Rho-kinase inhibitors specifically inhibit Rho-kinase function, thereby strongly attenuating diabetic complications. GGPP geranylgreanyl pyrophosphate, GEF guanine nucleotide exchange factors

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Renal Replacement Therapy

ISSN: 2059-1381

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