Serum albumin level adjusted with C-reactive protein predicts hemodialysis patient survival
Renal Replacement Therapy volume 3, Article number: 9 (2017)
Malnutrition-related conditions such as protein energy wasting are affecting poor outcome of the dialysis population. The serum albumin level is often used as a marker of wasting and malnutrition. However, the serum albumin level can be affected by the presence of inflammation as well as by nutritional status. We investigated associations between serum albumin values adjusted with C-reactive protein (CRP) and mortality in hemodialysis (HD) patients.
A total of 397 HD patients were included in this study. The patient characteristics and laboratory data, including serum albumin and CRP levels, were obtained in July 2012. Survival as of the end of August 2014 (maximum follow-up period 25 months) was investigated. First, the regression line was obtained from the entire population between serum albumin and CRP levels. Next, the CRP-adjusted albumin levels were determined as a dichotomized variable with the patients having higher albumin values above the regression line. We investigated associations between three albumin indices (the actual values, the dichotomized index by median, and CRP-adjusted values) and mortality by using Cox proportional hazard models.
The average age of the 397 HD patients was 70.6 years old; 258 were male, and 44.6% were diabetic. Median dialysis vintage was 3.6 years. There were 73 deaths during the observation period. A univariate Cox analysis demonstrated that all three indices were associated with survival, and the hazard ratio (HR) was 0.40 (95% confidence interval (CI) 0.25–0.68) for increase in albumin level, 0.41 (95% CI 0.25–0.68) for higher dichotomized albumin level by median, and 0.46 (95% CI 0.28–0.74) for higher CRP-adjusted albumin level, but only higher CRP-adjusted albumin level was associated with better survival (HR 0.51, 95% CI 0.30–0.85). The degree to which the deviation of albumin was attributable to that of CRP was 12.6%. The analyses on cause-specific mortality revealed that lower albumin levels were associated significantly with infection-related mortality but were not significantly associated with death due to congestive heart failure.
CRP-adjusted albumin was shown to be a better predictor of mortality among the HD patients. When assessing serum albumin values, inflammatory status should be taken into account. Malnutrition or wasting was shown to be associated with a poor outcome independent of inflammation.
The dialysis population in Japan is becoming older. Malnutrition-related conditions such as protein energy wasting (PEW) [1–4], sarcopenia [5, 6], and frailty [4, 7] draw attentions among such older dialysis populations. Many studies have investigated the relationship between malnutrition and patient outcome, and the results have revealed that malnutrition-related conditions are associated with a poor outcome [5–7].
To investigate the best index that reflects malnutrition is a matter of debate [8–12]. The serum albumin level is one of the most popular indexes of malnutrition [2, 8, 11, 12]. Albumin reportedly relates to the poor survival in original values , together with in a form of geriatric nutritional risk index (GNRI) . However, starvation does not necessarily reduce albumin values , and the inflammatory state that often coincides with malnutrition in dialysis populations  largely affects the lower albumin values . Thus, the serum albumin level might not be a suitable marker of malnutrition in dialysis patients.
We speculated that the values that deducted the effect of inflammation from the actual albumin might become a better marker of malnutrition compared to the original albumin values independent of the effect of inflammation. We therefore performed a study to investigate the relationship between the serum albumin levels and C-reactive protein (CRP) levels, and thereafter, the albumin values adjusted with CRP were investigated from the perspective of all-cause mortality of hemodialysis (HD) patients.
Design and population
This was a retrospective, observational cohort study conducted at a single center in Japan. The potential population was the chronic dialysis population that was on HD therapy through an arteriovenous fistula at Jyoban Hospital, Iwaki, Japan, in July 2012. HD patients with a malignancy, active inflammation, liver cirrhosis, gastrointestinal bleeding, cardiac valvular disease, or severe illness were excluded from participation and were transferred to another dialysis unit for intensive care. We also excluded the data of patients who did not consent to participate in this study. The Institutional Review Board of the Jyoban Hospital approved the study protocol; the approval number is 25-(3). The protocols were carried out in accordance with the Declaration of Helsinki guidelines regarding ethical principles for medical research involving human subjects. Informed consent was obtained from every subject.
The laboratory data were obtained on the basis of daily clinical practice. The biochemistry data and complete blood counts were obtained on the first day of each week. All measurements were made except the blood urea nitrogen (BUN) level before a dialysis session. BUN level was measured both before and after the dialysis session. Serum creatinine, calcium, phosphorus, albumin, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride were measured with an autoanalyzer by standard laboratory methods. The serum calcium values were corrected with albumin level. Intact parathyroid hormone (iPTH) was measured by an immunoradiometric assay. Body mass index (BMI) was expressed in kg/m2. Body weight was calculated as dry weight, defined as post-dialysis weight in which the patient was normotensive and with no signs of overhydration. Urea kinetics were assessed by measuring a blood-based dialysis parameter, Kt/V , and the mean value of the three measurements during each of the 3 months before the start of the study was used in the analysis. The normalized protein catabolic rate (nPCR) was used as an indirect indicator of protein intake and was calculated by using the formula previously reported .
The history of cardiovascular disease was defined from medical records showing previous heart failure, myocardial infarction, angina pectoris, stroke, coronary artery disease combined with stent implantation, and peripheral artery disease combined with percutaneous transluminal angioplasty.
Endpoints were obtained from the hospital charts and by telephone interview with patients that were conducted by trained interviewers who were blinded to the study protocol. The primary endpoint of this study was all-cause mortality during the follow-up period, from July 1, 2012 to August 31, 2014. The vital status of the subjects was assessed by searching their electronic dialysis records. Patients were censored if the patient was alive on August 31, 2014.
For the descriptive analysis, the mean values and standard deviations or median and interquartile ranges (IQRs) were used for normally or non-normally distributed continuous variables. Categorical variables were summarized by numbers and proportion.
The relationship between serum albumin and CRP levels was determined. Linear regression analysis was performed, and the predictive equation of albumin adjusted with CRP was determined. CRP is known to have a log-transformed normal distribution, and log CRP values were used to evaluate the relationship between the CRP and albumin. From the equation, the predicted albumin values that were adjusted with CRP levels were determined.
We performed the survival analysis by using the albumin indices as the main predictors. We used albumin indices in three ways: actual values, albumin dichotomized by the median, and CRP-adjusted albumin that was determined as high or low values, if the actual albumin values were higher or lower than predicted by the CRP levels. We performed Kaplan-Meier analyses followed by log-rank tests for the dichotomized albumin values by the median and CRP-adjusted albumin. Next, a Cox proportional hazard model was employed to evaluate survival effects of albumin. First, we performed univariate analyses, and then the models were adjusted for age, gender, diabetes, dialysis vintage, nPCR, and logCRP. Dialysis vintages were divided into four groups (<2 years, 2–4 years, 4–8 years, ≥8 years). Because the median dialysis vintage was 3.6 years and IQR was 1.6–7.5, such limits yielded almost quartilized groups in terms of the length of dialysis vintage. We used <2-year dialysis vintage group as the reference group. The effects of variables are expressed in the form of hazard ratios (HRs) and 95% confidence intervals (CIs).
We also performed similar survival analyses for the mortalities due to congestive heart failure and infective diseases. The causes of death were collected as the forms of semi-categorized disease entities. The deaths due to congestive heart failure were defined as the death due to itself, while the deaths due to infection included sepsis, pneumonia, and acute cholecystitis. The numbers of the deaths due to either congestive heart failure or infection were limited. Thus, in the multivariate analyses to investigate the associations of each albumin index with the cause-specific mortalities, we only adjusted age, gender, and diabetes as primary diagnoses. Actually, the numbers of deaths due to infection were small, and there remains a concern that we included more variables to adjust in the models. The degree of model fittings was also evaluated by the corrected Akaike’s Information Criteria (AICc). Furthermore, in order to investigate more detailed association, we also made a cross table for the numbers of the deceased patients by dichotomized albumin values and CRP-adjusted albumin values. The significance of this association was investigated by Fisher’s exact test.
The JMP 11.2.0 software program (SAS Institute Inc., NC, USA) was used to perform the statistical analysis.
Patient characteristics are shown in Table 1. The average age of the patients was 70.6 years old, which was slightly higher than the average age of total HD population of Japan (67.2 ± 12.5 years old at the end of 2013) . Diabetes and nephrosclerosis were the predominant primary diagnoses. One fourth of the patients had a history of cardiovascular disease.
The laboratory data are summarized in Table 2. The mean serum albumin value was 3.62 ± 0.38 g/dl (median 3.7, IQR 3.4–3.9). The median serum CRP value was 0.14 mg/dl, and the IQR was 0.05–0.38 mg/dl, which can be rephrased as logCRP −0.84 ± 0.62 (log mg/dl).
Figure 1 shows the relationship between the logCRP and albumin values, and a weak but significant correlation was found between the two sets of values. The regression equation was albumin (g/dl) = 3.438 − 0.215 logCRP (log mg/dl). The degree of fitting was expressed as R 2 = 0.126, which means that 12.6% of the albumin distribution was determined by the logCRP value.
The numbers of patients who died during the study period and their causes of death are summarized in Table 3. In total, 73 patients had died from all causes. The most common cause of death was heart failure (42.5%), and it was followed by infection (23.3%) and cerebrovascular disease (11.0%).
Kaplan-Meier analyses followed by log-rank tests demonstrated that both the higher dichotomized and CRP-adjusted albumin level groups were significantly associated with better survival (Fig. 2a, b). The univariate analysis was performed to investigate the relationships between each value and the all-cause mortality, and significant associations were found with age, log CRP, and albumin (Table 4). The relationship between serum albumin levels and mortality was investigated in three ways, as described above. The first was the actual value, the second was the dichotomized value, and the last was the albumin values adjusted with CRP. The CRP-adjusted albumin values were the dichotomized value that was determined by the albumin predicted from CRP values with the use of the regression equation, i.e., predicted albumin (g/dl) = 3.438 − 0.215 logCRP (log mg/dl). If the predicted values were smaller than the actual values, the CRP-adjusted albumin values were determined as low, vice versa. All three indices were significantly negatively correlated with all-cause mortality.
We investigated the predictive power of three albumin indices adjusted by age, gender, diabetes, dialysis vintage, nPCR, and logCRP. The HR for these indices was 0.60 (95% CI 0.29–1.23) for the actual serum albumin values, 0.64 (95% CI 0.37–1.08) for the dichotomized albumin values, and 0.51 (95% CI 0.30–0.85) for the CRP-adjusted albumin values. As a result, only CRP-adjusted albumin value was significantly associated with the poorer outcome (Table 5).
For cause-specific analyses, the lower groups for the albumin indices tended to be associated with lower mortality due to congestive heart failure but did not reach their significances by crude models. The HRs (and 95% CIs) for albumin indices were 0.44 (0.21–1.03), 0.52 (0.24–1.08), and 0.67 (0.32–1.37), for actual albumin values, dichotomized albumin values by the median, and CRP-adjusted albumin values, respectively. This association did not change even after adjustment of age, gender, and diabetes as primary diagnosis (Table 6). AICc is an index of the degree of model fitting, and the lower value demonstrates better model fitting. AICc demonstrated that CRP-adjusted albumin did not improve the degree of model fitting compared to other indices.
On the other hand, the associations between albumin indices and death due to infection were significant for all of the indices investigated by crude models. The HRs (and 95% CIs) for albumin indices were 0.22 (0.09–0.58), 0.12 (0.02–0.42), and 0.12 (0.02–0.41), for actual albumin values, dichotomized albumin values by the median, and CRP-adjusted albumin values, respectively. The associations did not change their significances. However, the CRP-adjusted albumin levels demonstrated the lower HR compared to that of the dichotomized albumin by the median. AICc of the model which included CRP-adjusted albumin was also the lowest among the three models, which indicates the model exhibited the best fitting (Table 7).
Table 8 indicated that the patients in the group with lower dichotomized by the median and lower CRP-adjusted albumin levels demonstrated higher infection-related mortality (p < 0.001), while the patients in the group with higher dichotomized by the median and higher CRP-adjusted levels demonstrated better survival (p = 0.005).
The results of this study showed that 12.6% of the deviation of albumin was determined by CRP. The CRP-adjusted albumin value was the only index associated with a poorer outcome of the chronic HD patients in this study. This result means that malnutrition or wasting itself was associated with survival, independent of the inflammation status, or protein intake of the chronic HD patients in this study. The analyses for cause-specific death demonstrated that such association was evident for death due to infection but not for congestive heart failure.
PEW is a condition in which visceral protein and fat stores decrease as a result of many chronic comorbid conditions, including chronic kidney disease [1, 2]. Since PEW has been shown to be associated with a poor outcome in many clinical investigations [1, 3, 4], strategies to combat PEW have been anticipated and discussed [1, 3]. The International Society of Renal Nutrition and Metabolism published diagnostic criteria for PEW . The guideline employed four clinical indices: serum chemistry (low serum levels of albumin, prealbumin, and cholesterol), body mass (reduced BMI, weight loss, and reduction of total body fat), muscle mass (muscle wasting, anthropometry, and creatinine appearance), and dietary intake (low dietary protein intake and energy intake) . Thus, reduced serum albumin level is closely related to PEW. Actually, the population with even minimal reduction of albumin as well as low albumin values reportedly experiences poor survival . The results from Kaplan-Meier analyses of this study confirmed such effects of albumin on mortality and demonstrated that lower albumin levels related to worse outcome.
Albumin is synthesized in the liver, and albumin synthesis is influenced by inflammation status  and amino acid pools [17, 18]. Moreover, inflammatory status shortens the half-life of serum albumin . Serum albumin level is therefore considered as an index of both inflammation and wasting or malnutrition [1, 14]. However, since dietary restriction does not always lead to a reduction in serum albumin level , the significance of inflammation has been postulated and been shown to outweigh the effect of malnutrition in determining the serum albumin levels . Likewise, the reduction of the serum albumin level is not necessarily caused by the malnutrition itself . An experiment in 1944 to 1945 investigated the effect of starvation on the physiological and psychological aspects of healthy volunteers. The results showed that only a limited reduction in serum albumin level (from 4.3 ± 0.5 to 3.9 ± 0.5 g/dl) was observed even after a severe decrease in body mass (BMI: from 21.7 ± 1.7 to 16.4 ± 0.9 kg/m2) . Moreover, the inflammation-related conditions or wasting are considered to have larger impacts on the reduction of albumin levels . Actually, the results of the present study indicated that 12.6% of deviation in albumin values was derived from those of CRP. Therefore, the degree was not so large, but it was demonstrated that albumin could be influenced by inflammation.
HD patients are prone to have inflammatory status because of the vascular access , periodontal diseases , bacterial translocation from the altered microbiome in the gut , or immunodeficiency . The presence of inflammation can be related to worse survival among HD patients [24, 25]; the HD patients with higher serum CRP level have higher mortality rates . However, the serum CRP levels of our study population were no longer associated with the poor outcome after adjustment for the serum albumin levels. This finding indicated that the significance of wasting or malnutrition might have larger impact on the better health of HD patients compared to inflammation.
This study demonstrated that such association was most evident for death due to infection. A study investigated the effect of albumin, which was not adjusted for CRP, on cause-specific mortality across hemodialysis and peritoneal dialysis . The study found that the HRs of low albumin levels for infection-related mortality were higher than those for cardiovascular mortality irrespective of dialysis modalities. Our study confirmed this result even by CRP-adjusted albumin. Moreover, the group with the lower CRP-adjusted albumin values more significantly associated, which was shown by the lower AICc score, with higher infection-related mortality compared to albumin indices. The fact indicated that lower albumin without the effect of inflammatory status was more likely associated with the death due to infection. Further studies are required to investigate whether hypoalbuminemia itself  or malnutrition existing in the background  is associated with infection-related mortality.
On the other hand, albumin values were not significantly associated with survival for the death due to congestive heart failure, though the point estimates of HRs favored the higher albumin values for all indices. This fact indicates that low albumin values can relate to the death due to congestive heart failure, but other factors seemed more likely to be associated with such mortality. Moreover, interestingly enough, CRP-adjusted albumin levels were no longer significant compared to other albumin indices. The previous reports demonstrated that hypoalbuminemia can relate to cardiovascular diseases [28, 29]. However, it has been demonstrated that there are many other cardiovascular risk factors, and the condition is known as cardiorenal syndrome type 4 . The present study confirmed that the death due to congestive heart failure might be associated with hypoalbuminemia itself, but more substantially with other risk factors as well. These associations require further investigations among larger cohorts.
Several indices, including the malnutrition-inflammation score  or GNRI , have been proposed to monitor the nutritional status of HD populations, and they have been reported to be good predictors of patient outcome [8, 11]. However, from a clinical standpoint, serum albumin levels can be monitored easily and are widely used to assess global nutritional status. The results of the present study demonstrated that it is important to consider inflammatory status of HD patients when assessing their serum albumin levels. This finding also indicates that malnutrition or wasting can affect the outcome of the patients independent of their inflammation status, thereby confirming the value of nutritional interventions to combat malnutrition in HD populations .
This study had several limitations. The first limitation was that it was performed on the basis of observational study, and thus, the cause result relationship cannot be drawn whether the outcome can be improved by the increase of serum albumin levels in face of higher CRP or the reduction of CRP in face of lower albumin levels. Second, this study was performed on the database of a single center. Further generalizability of the present investigation will be required by the study using the data of other cohorts. The final limitation was that only the baseline data were analyzed, and no changes in clinical indices, including albumin or CRP values, were considered. Substantial changes in the clinical parameters could take place afterward during the course. However, this study had several advantages. First, the total number of patients was substantial, and we were able to obtain a conclusion from this HD population. Second, the follow-up period and the numbers of outcomes are also sufficient to be investigated. Third, since the patient background factors almost matched those of the entire Japanese HD population. Therefore, the cohort in our study was the representative of the Japanese HD population.
When assessing the serum albumin levels of HD population, the inflammation status of the patients should be taken into consideration. Wasting or malnutrition itself can predict a worse outcome independent of inflammation.
Body mass index
Geriatric nutritional risk index
Normalized protein catabolic rate
Protein energy wasting
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Authors acknowledge all the participants and medical staffs who were engaged in the present investigations.
The authors did not have specific funding source to be disclosed.
Availability of data and materials
The cohort data used in this article contains anonymized but individual data. Therefore, we prefer not to share this database.
NH performed the statistical analysis and wrote the draft version of this article. KN and KT planned, organized, and directed the investigation, as well as finalized the manuscript. MO, MK, SS, and HK were in charge of the investigated patients, collected clinical data, and finalizing and reviewing the manuscript. All authors read and approved the final manuscript.
NH was a former member of the division funded by the Terumo Corporation. NH had a research contract concerning oral nutritional support on dialysis patients with Meiji Co., Ltd.
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This article does not contain any individual personal information. Therefore, this section is not applicable.
Ethics approval and consent to participate
The Institutional Review Board of the Jyoban Hospital approved the study protocol (no. 25-(3)), and the protocols were carried out in accordance with the Declaration of Helsinki guidelines regarding ethical principles for medical research involving human subjects. Informed consent was obtained from every subject. The written informed consent was obtained from the patients.
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Hanafusa, N., Nitta, K., Okazaki, M. et al. Serum albumin level adjusted with C-reactive protein predicts hemodialysis patient survival. Ren Replace Ther 3, 9 (2017). https://doi.org/10.1186/s41100-016-0085-4
- C-reactive protein
- Cohort study
- Protein energy wasting