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Modified A-DROP score and mortality in hemodialysis patients with pneumonia
Renal Replacement Therapy volume 3, Article number: 39 (2017)
Pneumonia is common in hemodialysis (HD) patients and has a poor prognosis, but there is little information on an accurate method for evaluating the severity of pneumonia, which is closely associated with prognosis, in HD patients. This study examined a method for evaluating the severity of pneumonia that was closely associated with 30-day mortality in HD patients.
This was a retrospective observational study of 64 HD patients. We determined the relationship between the severity of pneumonia using a modified A-DROP (excluding the dehydration section) score and 30-day mortality.
Nine patients (14.1%) died and 40% of patients with an A-DROP score of 3 or 4 died within 30 days. Logistic regression analysis showed that the A-DROP score was significantly associated with 30-day mortality. The discriminatory ability of the A-DROP score was assessed using area under the receiver operating characteristic curve analysis (0.810; 95% confidence interval 0.653–0.967; p < 0.01).
This modified A-DROP scoring system reflected the severity of pneumonia and was significantly associated with 30-day mortality. Patients with a modified A-DROP score of 3 or 4 had a poor prognosis.
Infectious diseases are one of the main causes of death among hemodialysis (HD) patients, and respiratory infectious diseases, especially pneumonia, are common and resulting in high mortality [1, 2]. HD patients who develop pneumonia are often difficult to treat because they are immune-compromised. They also tend to be elderly, and controlling the antibiotic dose is important [1, 2]. HD patients are also at high risk for blood stream-related infections  and methicillin-resistant Staphylococcus aureus or drug-resistant bacterial infections .
Pneumonia that develops in HD patients is included under the definitions of healthcare-associated pneumonia (HCAP)  and nursing and healthcare-associated pneumonia (NHCAP) . Previous reports have suggested that the bacteria causing pneumonia are the same in HD and HCAP patients [4, 7]. However, when evaluating the severity of pneumonia, it is important to differentiate pneumonia in HD patients from HCAP.
There are several scoring systems used to evaluate the severity of community-acquired pneumonia, such as the pneumonia severity index (PSI), CURB65, and A-DROP [8,9,10]. PSI is a well-known but complex index that includes blood urea nitrogen and pleural effusion and is strongly influenced by dialysis. CURB65 and A-DROP also include blood urea nitrogen [8,9,10].
It is possible that pneumonia in patients with HD should be distinguished from non-HD patients with HCAP. The method for evaluating the severity of pneumonia in HD patients has not been fully investigated, and the relationship between the severity of pneumonia and prognosis in HD patients is not completely understood.
The Japanese Respiratory Society has recommended that the A-DROP score is used for evaluating the severity of community-acquired pneumonia (CAP) . The A-DROP score is well-known and widely used in Japan. Although the A-DROP score is used for CAP and pneumonia in HD patients categorized as NHCAP , a previous report suggests that a very high A-DROP score should be included as a prognostic factor for NHCAP . In the current study, we adopted an A-DROP score based on a new scoring method, a “modified A-DROP score,” to evaluate the severity of pneumonia. The modified A-DROP score did not include the dehydration section. We aimed to clarify the usefulness of the modified A-DROP score for evaluating the severity of pneumonia, which is significantly associated with prognosis in HD patients.
This was a retrospective observational study. Between January 2011 and December 2016, 64 maintenance HD patients with newly developed pneumonia were admitted to Nagano Red Cross Hospital and all of them were enrolled in the study. The study protocol was approved by the institutional review board of the ethical committee at Nagano Red Cross Hospital and was conducted in accordance with the principles contained within the Declaration of Helsinki as revised in 2013.
Pneumonia was defined as the presence of newly developed infiltration on chest X-ray and/or computed tomography and an increase in serum markers of inflammation (C-reactive protein >0.3 mg/dL and/or white blood cell count >10,000/μL). History of cardiovascular disease included angina pectoris, acute myocardial infarction, cerebral hemorrhage, cerebral infarction, peripheral arterial disease, and aortic dissection. History of malignancy included solid tumors, such as colon cancer and gastric cancer, and hematological malignancies, such as lymphoma and myeloma. Chronic lung disease was defined as the presence of chronic obstructive pulmonary disease or interstitial pulmonary disease. Disorientation was evaluated as altered mentality. Altered mentality was defined as a decrease in Japan Coma Scale score. Hypoxia was defined as patients who could not maintain an oxygen saturation level greater than 90% without supplemental oxygen supply. The presence of infiltrates in two or more lobes on chest X-ray and/or computed tomography was defined as multi-lobar lesions. The severity of pneumonia was evaluated using A-DROP score (age [male >70, female >75], dehydration, respiratory failure, orientation disturbance, and low blood pressure) . In general, the dehydration section of the A-DROP scoring system is defined by blood urea nitrogen and physiological findings. In the current study, because our participants were HD patients, we excluded the dehydration section. Briefly, we defined the A-DROP score without including the dehydration section as the modified A-DROP score. The modified A-DROP score provided values of 0 to 4. Blood culture examinations were obtained within 24 h from admission and before the start of antibiotic therapy. Blood culture examinations were performed on either one or two sets. Clinical outcomes were defined as all-cause mortality within 30 days of hospital admission, clinical success of antibiotic therapy, duration of antibiotic therapy, and hospital mortality. Clinical success meant that pneumonia was successfully treated with the antibiotic selected at admission and that antibiotic was not changed except for the purpose of de-escalation. Failure of treatment was defined as death or a change in antibiotic from the initial therapy.
Continuous variables between the two groups were compared using the Mann–Whitney U test, and categorical variables were compared using Fisher’s exact probability test. Continuous variables among three groups were compared using the Kruskal–Wallis test, and multiple comparisons between two groups were compared using the Mann–Whitney U test with Bonferroni correction. Factors associated with the clinical outcomes were analyzed using logistic regression analyses. The discriminatory ability of the factors was evaluated using the area under the receiver operating characteristic curve (AUC) analysis. A p value <0.05 was considered statistically significant. Analyses were performed using EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan), which is a graphical user interface for R (the R Foundation for Statistical Computing, Vienna, Austria) .
The clinical characteristics of all 64 patients are shown in Table 1. The median age was 75 years. Forty-seven patients were male and 17 female. The main cause of HD was diabetic nephropathy (27 patients, 42.2%). Arteriovenous fistula or arteriovenous graft was the main type of vascular access. Thirty-four patients (53.1%) had cardiovascular disease complications, 21 (32.8%) had altered mentality, and 45 (70.3%) had hypoxia. Blood culture examinations were performed for 47 patients (73.4%), and three patients (6.4%) were positive. Forty-two patients (65.6%) had multi-lobar lung infiltration, and 43 patients (67.2%) had pleural effusion. The severities of pneumonia evaluated using the modified A-DROP score were eight patients (12.5%) scored 0, 19 (29.7%) scored 1, 22 (34.4%) scored 2, 13 (20.3%) scored 3, and two (3.1%) scored 4. Nine patients (14.1%) died within 30 days of hospitalization, and 11 patients (17.2%) died in the all hospitalization period.
Severity of pneumonia and clinical outcomes
One patient (3.7%) with a modified A-DROP score of 0 or 1 died, two patients (9.1%) with a modified A-DROP score of 2 died, and six patients (40.0%) with a modified A-DROP score of 3 or 4 died within 30 days of hospitalization (Fig. 1). Forty-six patients (71.9%) were successfully treated with initial antibiotic therapy. The median duration of antibiotic therapy was 11 days. The clinical characteristics among the three groups (modified A-DROP score 0 or 1, 2 or 3, or 4) is shown in Table 2. Age, altered mentality, hypoxia, pleural effusion, duration of antibiotic therapy, 30-day mortality, and hospital mortality were significantly different among the three groups. Logistic regression analysis showed that the modified A-DROP score was significantly associated with 30-day mortality (Table 3). The discriminatory ability of the modified A-DROP score was assessed using AUC analysis (AUC 0.810; 95%CI 0.653–0.967; p < 0.01) (Fig. 2).
Bacteria and antibiotic therapy
α-Streptococcus, Candida, Neisseria, and S. aureus were the main pathogens detected in sputum cultures, while Streptococcus pneumoniae and Branhamella catarrhalis were detected in a few cases only (Table 4). Klebsiella pneumoniae was detected in two patients and S. pneumoniae was detected in one patient from blood cultures. Ampicillin/sulbactam, tazobactam/piperacillin, and meropenem were the main initial antibiotic therapies (Table 5).
Previous studies have reported hospital mortality from pneumonia in HD patients as 12.4% and 30-day mortality as 11.6% [1, 13]. In the current study, 30-day mortality was 14.1% and prognosis was similar as the previous studies. A previous study compared the prognosis between HD patients with pneumonia and patients with HCAP and did not find a significant difference . In addition, the bacteria causing pneumonia in HD patients and HCAP are similar. Thus, the clinical characteristics between the two groups are similar.
When predicting the prognosis of pneumonia or evaluating the severity of pneumonia, either the PSI, CURB65, or A-DROP scoring systems are used. However, these scoring systems include blood urea nitrogen, dehydration, or pleural effusion [8,9,10], which are strongly influenced by renal impairment and dialysis. This means that it is difficult to accurately evaluate the severity of pneumonia in dialysis patients. In such patients, the severity of pneumonia should be evaluated using a scoring system that excludes those factors associated with kidney function or dialysis.
In the current study, we used the A-DROP scoring system but excluded the dehydration section to evaluate the severity of pneumonia in HD patients. The modified A-DROP score was found to be significantly associated with prognosis in HD patients with pneumonia. It is suggested that the modified A-DROP score is useful for evaluating the severity of pneumonia in HD patients. A benefit of this system is that clinical data (age, blood pressure, orientation, and hypoxia) are easy to obtain and do not require blood examinations. In short, the modified A-DROP score is a good and convenient option not only in hospitals but also in HD clinics.
With regard to the bacteria isolated from sputum cultures, gram-positive coccus such as α-Streptococcus and S. aureus were the main species detected. S. pneumoniae and B. catarrhalis are often detected in non-HD patients presenting with pneumonia [14, 15]. A previous study by Kawasaki et al. reported that S. pneumonia is the second most frequently detected pathogen in HD patients with pneumonia . However, S. pneumonia and B. catarrhalis were detected in only a few cases. Most patients were elderly and some presented with dysphagia and might develop aspiration pneumonia. Therefore, the detected bacteria were not S. pneumonia or B. catarrhalis but indigenous bacterium of the oral cavity such as α-Streptococcus.
This study examined HD patients, who have an increased risk for blood stream infections; however, there were only three patients (6.4%) with positive blood cultures. A previous study of non-HD patients with pneumonia reported a positive blood culture rate of 5.7%, and it was not associated with the severity of pneumonia evaluated using PSI . These results suggest that blood culture examination is not useful for detecting the causative microorganism in patients with bacterial pneumonia. Recently, routine blood culture examinations have been not recommended for patients presenting with pneumonia .
This study had some limitations. We could not fully evaluate the severity of pneumonia using CURB65 or PSI. Because we could not obtain data for respiration rates, we evaluated the severity of pneumonia using the modified A-DROP score. Although smoking is a risk factor for community-acquired pneumonia , we were unable to obtain patient smoking histories. Bedridden patients or patients with dysphagia often have repeated aspiration pneumonia and have a poor prognosis, and activities of daily living and cognitive impairment are important for the prognosis of pneumonia . However, we could not obtain data about patients’ activities of daily living or cognitive function. Although this study had a small sample size, we collected and analyzed clinical data such as the severity of pneumonia and prognosis, duration of antibiotic therapy, and success of initial therapy in details. We could not diagnose whether a patient had aspiration pneumonia as it is difficult to correctly diagnose if a patient presenting with pneumonia has aspiration pneumonia. Because information of the quality of sputum could not be obtained, some sputum samples mainly contained salivary contents, resulting detecting indigenous bacterium of the oral cavity.
We could not unify the timing of evaluation of the modified A-DROP score in the current study. Therefore, we examined when the modified A-DROP score was evaluated. According to the timing of HD sessions, we divided the timing of the modified A-DROP score evaluation into three groups: (1) before HD sessions, (2) between HD sessions, and (3) after HD sessions. Eighteen patients were evaluated for the modified A-DROP score before HD sessions, 25 were evaluated between HD sessions, and 21 were evaluated after HD sessions. Because it is possible that blood pressure, fluid volume, and hypoxia can change depending on the timing of a HD session, and this can influence the evaluation of the A-DROP score (as well as the modified A-DROP score being influenced by when the modified A-DROP score was evaluated), we compared the frequency of the modified A-DROP score among the three groups (before HD sessions, between HD sessions, and after HD sessions). As a result, the frequency of the modified A-DROP score was not significantly different among the groups (Additional file 1: Table S1). However, not unifying the timing of evaluation of the modified A-DROP score is a limitation of the current study.
In conclusion, the modified A-DROP score reflected the severity of pneumonia and was significantly associated with 30-day mortality in this population of HD patients. Patients with a modified A-DROP score of 3 or 4 had a poor prognosis.
Area under the receiver operating characteristic curve
Pneumonia severity index
Slinin Y, Foley RN, Collins AJ. Clinical epidemiology of pneumonia in hemodialysis patients: the USRDS waves 1, 3, and 4 study. Kidney Int. 2006;70:1135–41.
Sarnak MJ, Jaber BL. Pulmonary infectious mortality among patients with end-stage renal disease. Chest. 2001;120:1883–7.
Patel PR, Yi SH, Booth S, Bren V, Downham G, Hess S, et al. Bloodstream infection rates in outpatient hemodialysis facilities participating in a collaborative prevention effort: a quality improvement report. Am J Kidney Dis. 2013;62:322–30.
Wang PH, Wang HC. Risk factors to predict drug-resistant pathogens in hemodialysis-associated pneumonia. BMC Infect Dis. 2016;16:377.
Kollef MH, Morrow LE, Baughman RP, Craven DE, McGowan Jr JE, Micek ST, et al. Health care-associated pneumonia (HCAP): a critical appraisal to improve identification, management, and outcomes—proceedings of the HCAP Summit. Clin Infect Dis. 2008;46 Suppl 4:S296–334.
Kohno S, Imamura Y, Shindo Y, Seki M, Ishida T, Teramoto S, et al. Clinical practice guidelines for nursing- and healthcare-associated pneumonia (NHCAP). Respir Investig. 2013;51:103–26 [complete translation].
Lee JH, Moon JC. Clinical characteristics of patients with hemodialysis-associated pneumonia compared to patients with non-hemodialysis community-onset pneumonia. Respir Med. 2016;111:84–90.
Arnold FW, Ramirez JA, McDonald LC, Xia EL. Hospitalization for community-acquired pneumonia: the pneumonia severity index vs clinical judgment. Chest. 2003;124:121–4.
Barlow G, Nathwani D, Davey P. The CURB65 pneumonia severity score outperforms generic sepsis and early warning scores in predicting mortality in community-acquired pneumonia. Thorax. 2007;62:253–9.
Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Imaizumi K, et al. Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia. Respirology. 2008;13:731–5.
Oshitani Y, Nagai H, Matsui H, Aoshima M. Reevaluation of the Japanese guideline for healthcare-associated pneumonia in a medium-sized community hospital in Japan. J Infect Chemother. 2013;19:579–87.
Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.
Kawasaki S, Aoki N, Kikuchi H, Nakayama H, Saito N, Shimada H, et al. Clinical and microbiological evaluation of hemodialysis-associated pneumonia (HDAP): should HDAP be included in healthcare-associated pneumonia? J Infect Chemother. 2011;17:640–5.
Saito A, Kohno S, Matsushima T, Watanabe A, Oizumi K, Yamaguchi K, et al. Prospective multicenter study of the causative organisms of community-acquired pneumonia in adults in Japan. J Infect Chemother. 2006;12:63–9.
Ishida T, Hashimoto T, Arita M, Tojo Y, Tachibana H, Jinnai M. A 3-year prospective study of a urinary antigen-detection test for Streptococcus pneumoniae in community-acquired pneumonia: utility and clinical impact on the reported etiology. J Infect Chemother. 2004;10:359–63.
Campbell SG, Marrie TJ, Anstey R, Dickinson G, Ackroyd-Stolarz S. The contribution of blood cultures to the clinical management of adult patients admitted to the hospital with community-acquired pneumonia: a prospective observational study. Chest. 2003;123:1142–50.
Wunderink RG, Waterer GW. Clinical practice. Community-acquired pneumonia. N Engl J Med. 2014;370:543–51.
Baik I, Curhan GC, Rimm EB, Bendich A, Willett WC, Fawzi WW. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med. 2000;160:3082–8.
Salive ME, Satterfield S, Ostfeld AM, Wallace RB, Havlik RJ. Disability and cognitive impairment are risk factors for pneumonia-related mortality in older adults. Public Health Rep. 1993;108:314–22.
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The study protocol was approved by the institutional review board of the ethical committee at Nagano Red Cross Hospital and was conducted in accordance with the principles contained within the Declaration of Helsinki as revised in 2013.
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