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Surgical considerations in paediatric kidney transplantation: an update
Renal Replacement Therapy volume 7, Article number: 54 (2021)
Kidney transplantation has established itself as the most appropriate mode of renal replacement therapy for the majority with end-stage kidney disease. Although at present this is applicable for children as well as adults, a few decades back kidney transplantation was not considered a first-line option in children. This was due to inferior outcomes following transplantation in this age group compared to that of adults. These poor results were attributed to challenges in paediatric transplantation such as the shortage of suitable donors, technical difficulties in performing a sound vascular anastomosis and the adverse effects of immunosuppressive medication on growth and development. However, current patient and graft-centred outcomes after paediatric transplantation equal or surpass that of adults. The advances in evaluation and management of specific surgical concerns in children who undergo transplantation, such as pre-transplant native nephrectomy, correction of congenital anomalies of the urinary tract, placement of an adult-sized kidney in a small child and minimizing the risk of allograft thrombosis, have contributed immensely for these remarkable outcomes.
In this review, we aim to discuss surgical factors that can be considered unique for children undergoing kidney transplantation. We believe that an updated knowledge on these issues will be invaluable for transplant clinicians, who are dealing with paediatric kidney transplantation.
The first successful kidney transplantation (KT) between an adult donor–recipient pair was performed in 1954 . Since then, major advances in immunosuppression, surgical technique and post-transplant medical care have substantially improved the outcomes of this procedure. These favourable results that were achieved in adults who underwent transplantation were initially not reproduced in children. They had dismal graft and patient outcomes after transplantation. Thus, children with end-stage kidney disease (ESKD) were allowed to die because there seemed to be no suitable mode of long-term renal replacement therapy for them (RRT) .
In 1983, Miller and colleagues published their experience in transplanting 12 children with a bodyweight < 9 kgs, and they reported long-term outcomes similar to contemporary adult transplant recipients . These results reignited interest in KT as a suitable option for RRT in children. Presently, the short-term and long-term outcomes of kidney transplants done in children are superior or equal to that of adults, and transplantation is considered the best mode of RRT in children as well .
Children with ESKD are different from adults with regard to aetiology of their native kidney disease and the impact of kidney disease on their growth and development. The most common diseases that predispose to chronic renal failure in this age group are congenital anomalies of the kidney and the urinary tract (CAKUT), congenital nephrotic syndrome (CNS), cystic disease of the kidneys, renal dysplasia and aplasia. This is in contrast with adults who suffer ESKD mainly secondary to complications of diabetes or hypertension . Children with pathologies such as intractable proteinuria due to CNS and recurrent infections due to reflux nephropathy may require native nephrectomy prior to transplantation. Those who have CAKUT need a thorough evaluation of the anatomy and the function of the urinary system. Due to their small-body proportions, finding adequate space for placement of adult-sized kidney (ASK) allografts in children can be challenging. Anastomosing the renal artery and the vein to small caliber paediatric vessels is a technically demanding task, and such anastomoses are more at risk of thrombosis. Post-operative complications after kidney transplant such as urine leak and lymphocele are seen in children as well, and they are managed according to the same principles as in adults.
In this review, we aim to address specific surgical concerns that have a bearing on the outcomes of kidney transplantation in children, namely the place of native nephrectomy, issues related to CAKUT, and surgical considerations with a special emphasis on organ placement and allograft thrombosis.
Indications and timing of native nephrectomy
Unilateral or bilateral native nephrectomy is performed in paediatric transplant candidates if the native kidneys confer a threat to patient or graft survival after transplantation . The common indications for such nephrectomy in children are CNS with massive proteinuria (> 40 mg/m2/h), polyuria (> 2.5 ml/kg/h), hypertension refractory to medical management, recurrent urinary infections with upper tract dilatation, malignancy or conditions that may confer a high risk of future malignancy and space-limiting cystic kidney disease [5, 6].
Proteinuria associated with CNS will create a pro-coagulant state that can precipitate allograft thrombosis and venous thromboembolism. Significant proteinuria can deplete body protein reserves, which will adversely affect the child’s growth. Post-transplant fluid and electrolyte management will be difficult in children with ESKD who produce large volumes of urine. They are more at risk of hypovolemia that can threaten graft perfusion . Denys-Drash syndrome is a condition with a predilection for nephroblastoma and those affected will benefit from prophylactic nephrectomy before transplantation . Brubaker et al. has reported better blood pressure control and reduced requirement for antihypertensive drugs in children who have had their native kidneys removed. This was considered an advantage by the authors, as children are prone to poor compliance .
However, there are certain disadvantages of pre-transplantation nephrectomy as well. Anuria after bilateral nephrectomy will complicate fluid, electrolyte, acid–base homeostasis and push the child towards dialysis. The production of erythropoietin and vitamin D3 by the native kidneys will completely lost, and this can potentially worsen renal anaemia and mineral bone disease .
Native nephrectomy can be done as a staged procedure where transplantation follows nephrectomy. Alternatively, it can be done at the time of transplantation. Another strategy is to perform a uni-nephrectomy before the transplant and to remove the remaining kidney at the time of transplant. This method preserves the function of the remaining kidney and may allow pre-emptive transplantation [5, 9]. Patients with CNS and polyuria are likely to have a staged procedure, while patients with reflux nephropathy and recurrent infections tend to undergo simultaneous nephroureterectomy at the time of transplant. According to Kizilbash et al., there were no differences in the patient or graft-centred outcomes with regard to timing of native nephrectomy . The advantages of a simultaneous procedure are the ability to avoid a second hospital admission and a general anaesthetic. Additionally, it preserves the tissue planes around the aorta and the inferior vena cava (IVC) and allows easy exposure and control of these vessels for implantation of the allograft. The disadvantages of a simultaneous approach are the prolonged operative times that places the child at a higher risk of anaesthetic and surgical complications and the chances of sepsis in the immediate post-transplant period if the nephrectomy is done for recurrent infections.
Minimally invasive techniques are preferred over open surgery for pre-transplant nephrectomy in children. Trans-peritoneal and retro-peritoneal techniques have been used with equal success [5, 6]. When simultaneous bilateral nephrectomy is performed at the time of transplantation, the approach through a midline laparotomy allows access for both procedures .
Medical nephrectomy by using angiotensin-converting inhibitors and non-steroidal anti-inflammatory drugs is an alternative to surgical removal of the kidneys. According to Vo et al., who published the results of such an approach in eight children with CNS, 6/8 were able to avoid surgery .
Congenital anomalies in the kidney and the urinary tract; Pre-operative evaluation and management
CAKUT is a leading cause of ESKD in children and poses unique challenges concerning transplantation . All children who are considered for renal transplantation require evaluation of their kidneys, ureters and bladder by an ultrasound scan (USS). If there is a history of recurrent urinary tract infections (UTIs), surgery or instrumentation of the urinary tract or urinary incontinence, a micturition cystourethrogram is indicated [12, 13]. When bladder dysfunction is suspected, urodynamic studies are an essential component of the pre-transplant workup. These tests will provide useful information with regard to characteristics of the detrusor muscle, bladder volume, post-void residual urine volume and urine leakage .
Before implantation of a transplant ureter onto an abnormal bladder, the operating surgeon should be confident that lower urinary tract obstruction and neurogenic bladder dysfunction have been excluded or adequately addressed . Small capacity bladders that are secondary to anuria or oliguria that do not have associated voiding dysfunction can be expected to expand in volume once the urine output increases after transplant .
The transplant ureter can be implanted to a neurogenic bladder in a well-motivated child who is adequately trained in clean intermittent catheterization (CIC). Anticholinergics are a useful adjunct in this situation. Urinary diversion and bladder augmentation are alternatives when the native bladder is unsuitable .
Bladder augmentation aims to create an adequate capacity, low-pressure urine reservoir that can be emptied by straining or CIC. The child and the caregivers should be appropriately educated and trained on the technique of CIC before embarking on this procedure. Detubularized, dilated native ureters are preferred as the first line option to increase the bladder capacity. In those who have undergone prior ureteric reimplantation, nephroureterectomy or in the presence of non-dilated ureters, segments of the ileum, sigmoid colon or the stomach are the second, third and fourth options in order of preference. Use of intestinal segments for bladder augmentation can be associated with complications such as hyperchloremic acidosis, abnormalities in calcium metabolism, growth retardation and malignant transformation. Haematuria-dysuria syndrome is an uncommon complication of gastrocystoplasty .
When transplanting children who have had a bladder augmentation, the ureteroneocystostomy is preferentially performed on to the native bladder. When the native bladder is unsuitable for this purpose, the transplant ureter is anastomosed to the augmented portion of the bladder .
Children with lower urinary tracts that are not amenable for reconstruction or those who lack the capacity for CIC will benefit from an ileal conduit. Alternatively, a continent urinary diversion such as a Mitrafanoff procedure can be considered in a child who has the capacity for CIC .
Timing of bladder augmentation in children with ESKD and bladder dysfunction is a controversial topic with a limited evidence base . Those who advocate pre-transplant bladder augmentation believe that a complex bladder reconstruction while on immunosuppression may predispose to poor wound healing and increased surgical complications. A 3-month interval is recommended when transplantation is done after bladder augmentation. During this waiting period, an anuric or oliguric patient will need regular bladder washouts to maintain its capacity and to clear the accumulated intestinal secretions. Additionally, implantation of the transplant ureter into a ‘dry’ bladder is such patients may precipitate urosepsis .
Augmentation of the bladder after transplantation potentially avoids these issues. However, reconstruction will be done while the patient is under immunosuppression. An alternative method of urinary drainage such as a suprapubic catheter will be required for adequate emptying of the bladder until it is augmented. Operating in the child’s pelvis after transplantation has the potential to damage the transplant ureter and its vascular pedicle .
According to available data, the timing of bladder augmentation does not have an impact on the patient and graft survival after paediatric KT. The incidence of post-operative complications seems to be comparable in both these approaches [16, 17]. So, the decision is at the discretion of the operating team, who have to consider the advantages and disadvantages on a case by case basis.
Outcomes of paediatric KT on a background of CAKUT
Historically, children with ESKD due to CAKUT were excluded from transplantation as their outcomes were considered to be extremely poor . However, this has been proven incorrect, and there is conclusive evidence that children who have had kidney transplantation with a background of adequately managed dysfunctional bladder or lower urinary tract anomaly achieve comparable graft and patient survival to those who do not have such problems [18,19,20,21,22]. The risk of post-transplant UTI in such children appears to be significantly high, although the impact of such infection on graft and patient outcomes is not clear [14, 19]. Long-term, low-dose antibiotic prophylaxis in post-transplant children with a reconstructed bladder will reduce the incidence of such UTIs [20, 23]. It is agreed that children who have had a KT with a bladder augmentation or urinary diversion require life-long surveillance for urological complications.
Transplant surgical considerations
Placement of an ASK in a small child can be technically challenging, but this task has been successfully achieved in children weighing less than 10 kgs . Both intraperitoneal and extraperitoneal spaces have been used for this purpose with equal outcomes . Rosenthal and associates used the intraperitoneal approach when the bodyweight of the child was < 10 kgs. For those with a bodyweight > 15 kg, they preferentially used extraperitoneal space. When the child weighed between 10 and 15 kgs, an individualized decision was taken after considering the size of the recipient and the donor's kidney . Successful extraperitoneal engraftment of ASKs in children weighing around 8kgs has been reported .
The intraperitoneal approach is via a midline incision, and the ASK is preferentially placed in the right side of the abdomen after mobilizing the ascending colon and the terminal ileum medially to expose the common iliac vessels, aorta and the IVC. For extraperitoneal placement of the graft, a J-shaped incision is made on the right or left side of the abdomen and the peritoneum is mobilized medially and upwards to expose the recipient’s posterior abdominal wall with its blood vessels . The proposed advantages of the extraperitoneal technique are the reduced incidence of early and late gastrointestinal complications such as ileus and adhesive small bowel obstruction and the ability to continue peritoneal dialysis (PD) in the post-operative period for those children who are established on PD .
After placing an ASK in a child, tension-free primary closure of the abdominal wall can become a dilemma. Techniques such as muscle flaps and bioprosthetic meshes have been used with acceptable success to overcome this issue .
A technically sound vascular anastomosis is crucial for the success of the transplant. Large-diameter arteries and veins such as the aorta, IVC and the common iliac vessels are preferred as inflow and outflow vessels in children. In an infant or a very small child, there can be a marked discrepancy between the caliber of the recipient’s blood vessels and the donor’s renal artery and vein. As a general size comparison, the aorta in an infant will have a diameter equal to an adult renal artery and the adult renal vein can have a diameter that is three times that of an infant’s IVC. When the ASK is transplanted to a small child, it is important to avoid redundancy in the vascular pedicle to avoid a kink or a twist that may precipitate thrombosis. The right renal vein is short and thin walled and leaving a cuff of donor IVC with it will make the anastomosis easier. Both the venous and arterial anastomoses are done with fine, monofilament, non-absorbable sutures. It is preferable to do at least half of the arterial anastomosis with interrupted sutures to prevent a purse string effect .
Sequential clamping of the recipient's vein and the artery rather than clamping them both at the start of the anastomosis will limit the time of lower extremity ischaemia and the resultant metabolic acidosis. Confirming the haemostasis of the venous suture line before performing arterial anastomosis is recommended, as it provides more access and manoeuverability for additional suture placement  (Table 1).
Prevention of allograft thrombosis
Allograft thrombosis is a major cause of early graft loss after paediatric KT. According to the US kidney transplant data from 1996 to 2001, it was the leading cause of graft loss in children. A history of PD, young donor and recipient age, organs from deceased donors and prolonged cold ischaemia times have been identified as risk factors for this complication .
Thrombophilic conditions have been associated with renal vein thrombosis in adult transplants, but large studies that address outcomes of transplantation in children with such conditions are not available . In their case series, Dick et al. reported excellent results following KT in three children with inherited thrombophilic conditions. All three received perioperative anticoagulation, which was continued up to 6–12 months after the transplant .
Prophylactic heparin and aspirin have been used with some success for the prevention of allograft thrombosis in children who are at risk of this complication . According to Kim and colleagues, there is no added advantage of routine perioperative anticoagulation in small children who lack risk factors for allograft thrombosis . In contrast, Esfandiar et al. who used empirical treatment with heparin and aspirin in 24 children undergoing KT reported zero thrombotic events . Studies that compare the efficacy and safety of antiplatelet drugs vs anticoagulants for the prevention of allograft thrombosis in children are not available at present. In addition, with regards to paediatric KT, currently, there is no consensus on the most suitable antithrombotic regimen nor who should receive such treatment . So, an individualized approach considering the risks vs benefits of such therapy should be followed to determine the need for perioperative anticoagulation in children undergoing KT.
As described above, meticulous technique and attention to detail during vascular anastomosis are crucial to prevent technical errors that may predispose to thrombosis. Use of larger recipient vessels with high flow rates such as the aorta and the IVC, tilting the fluid balance of the child towards overhydration during the surgery and immediate post-transplant period are other important considerations that can reduce the risk of thrombosis . Daily duplex surveillance of the allograft after paediatric KT has been recommended by some authors to facilitate the early detection of thrombotic complications .
KT is the ideal mode of RRT for paediatric patients with ESKD. Thorough pre-transplant evaluation and preparation, meticulous surgical technique and optimum post-transplant care have contributed to excellent short-term and long-term results in children after such transplants. With regard to paediatric KT, there are multiple unique surgical aspects. Adequate understanding and appropriate attention to these issues will have a direct impact on successful outcomes.
Availability of data and materials
End-stage kidney disease
Renal replacement therapy
Congenital anomalies of the kidney and the urinary tract
Congenital nephrotic syndrome
Inferior vena cava
Urinary tract infection
Clean intermittent catheterization
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Gunawardena, T., Sharma, H., Sharma, A.K. et al. Surgical considerations in paediatric kidney transplantation: an update. Ren Replace Ther 7, 54 (2021). https://doi.org/10.1186/s41100-021-00373-5
- Paediatric kidney transplant
- Surgical issues