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  1. Content type: Research

    For continuous venovenous hemofiltration (CVVH) to achieve an adequate therapeutic effect, prolonged stable administration and a long circuit lifetime are needed. The effects of hemofilters produced using vari...

    Authors: Yuki Nakamura, Shinya Chihara, Hiroomi Tatsumi and Yoshiki Masuda

    Citation: Renal Replacement Therapy 2019 5:1

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  2. Content type: Case Report

    Sleep apnea syndrome (SAS) is a sleep disturbance, which is frequently comorbid in dialysis patients. SAS induces hypoxia, and therefore, systemic and cerebral oxygenation would be low. Near-infrared spectrosc...

    Authors: Kiyonori Ito, Susumu Ookawara, Mariko Fueki, Sojiro Imai, Takashi Hattori, Satoshi Kiryu, Yukari Sugai, Noriko Wada, Mitsutoshi Shindo, Yasushi Ohnishi, Noriaki Iino, Kaoru Tabei and Yoshiyuki Morishita

    Citation: Renal Replacement Therapy 2018 4:54

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  3. Content type: Review

    For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovascular disease. One of the main novel risk factors is oxidative stress, which occurs when there is overproduction of re...

    Authors: Xiao Chun Ling and Ko-Lin Kuo

    Citation: Renal Replacement Therapy 2018 4:53

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  4. Content type: Case Report

    Peritoneal dialysis (PD)-associated peritonitis caused by nontuberculous mycobacteria (NTM), including Mycobacterium abscessus (M. abscessus), is a rare but serious complication that forces PD to be withdrawn. Se...

    Authors: Erina Ono, Eiichiro Uchino, Keita P. Mori, Hideki Yokoi, Naohiro Toda, Kenichi Koga, Masato Kasahara, Takeshi Matsubara and Motoko Yanagita

    Citation: Renal Replacement Therapy 2018 4:52

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  5. Content type: Research

    It remains unclear whether hepatitis C virus (HCV)-infected Japanese patients on hemodialysis (HD) have an altered viral response to glecaprevir (GLE) and pibrentasvir (PIB) combination therapy and whether thi...

    Authors: Yoshiaki Tanaka, Takanori Masaki, Haruki Uojima, Takayasu Ohtake, Tomoaki Fujikawa, Yasuhiro Yamanouchi, Naohisa Wada, Kousuke Kubota, Hisashi Hidaka, Takahide Nakazawa, Akitaka Shibuya, Togo Aoyama, Ji Hyun Sung, Makoto Kako, Shuzo Kobayashi, Yasuo Takeuchi…

    Citation: Renal Replacement Therapy 2018 4:51

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  6. Content type: Research

    Orthostatic hypotension is a risk factor for falls among chronic hemodialysis (HD) patients. This study aimed to investigate the hemodynamic response to orthostatic stress immediately after an HD session. Twen...

    Authors: Toshiyuki Mochizuki, Yoshimi Matsuo, Mayumi Sasaki, Kenichi Morihisa, Sakuyoshi Tabata, Toyofumi Fukuda and Ibuki Yajima

    Citation: Renal Replacement Therapy 2018 4:49

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  7. Content type: Research

    Poor nutritional status and functional impairment are common in patients with end-stage renal disease (ERSD) on maintenance hemodialysis (MHD). Although nutritional status is associated with functional depende...

    Authors: Yoshitaka Shimizu, Tatsu Fujiura and Hidetaka Wakabayashi

    Citation: Renal Replacement Therapy 2018 4:48

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  8. Content type: Case Report

    Peritoneal dialysis (PD) access is important for patients undergoing PD. However, one of the potential complications of peritoneal dialysis access is damage to the dialysis tubing. Although most dialysis tubin...

    Authors: Toshihide Naganuma, Yoshiaki Takemoto, Junji Uchida and Tatsuya Nakatani

    Citation: Renal Replacement Therapy 2018 4:47

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  9. Content type: Case Report

    Vertebral arteriovenous fistula (AVF) is an uncommon vascular disorder and defined as abnormal connections of the extracranial vertebral artery or its branches into the neighboring vein or deep venous plexus. ...

    Authors: Kinuko Dote, Nobuyuki Takahashi, Tomoko Niki, Tomoya Ishiguro and Ichiro Shiojima

    Citation: Renal Replacement Therapy 2018 4:44

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  10. Content type: Position statement

    The annual survey of The Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was conducted for 4396 dialysis facilities at the end of 2016, among which 4336 facilities (98.6%) responded. The response...

    Authors: Ikuto Masakane, Masatomo Taniguchi, Shigeru Nakai, Kenji Tsuchida, Atsushi Wada, Satoshi Ogata, Takeshi Hasegawa, Takayuki Hamano, Norio Hanafusa, Junichi Hoshino, Shunsuke Goto, Keiichi Yamamoto, Jun Minakuchi and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2018 4:45

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  11. Content type: Research

    Vascular access (VA) intervention therapy (VAIVT) has been increasingly used for treating VA failure (VAF) in patients undergoing hemodialysis; however, clinical evidence demonstrating the efficacy of preventi...

    Authors: Tomohito Mizuno, Motonobu Nakamura, Nobuhiko Satoh, Hiroyuki Tsukada, Akihiko Matsumoto, Yoshifumi Hamasaki, Haruki Kume and Masaomi Nangaku

    Citation: Renal Replacement Therapy 2018 4:43

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  12. Content type: Research

    Intradialytic plasma volume change (IPVC) owing to ultrafiltration is a dominant cause of intradialytic hypotension (IDH). Lower occurrence of IDH in hemodiafiltration (HDF) than in standard hemodialysis (std-...

    Authors: Masayuki Tanemoto, Yu Ishimoto, Yukio Kosako and Yukio Okazaki

    Citation: Renal Replacement Therapy 2018 4:42

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  13. Content type: Position statement

    A newspaper article in August 2016 reported that about 40 medical facilities refused dialysis to a human immunodeficiency virus (HIV) patient. Infection Survey Subcommittee in the Japanese Society for Dialysis...

    Authors: Ayumi Yoshifuji, Munekazu Ryuzaki, Yasuhiko Ito, Norio Ohmagari, Yoshihiko Kanno, Toshio Shinoda, Yaoko Takano, Isao Tsukamoto, Kazuhiko Hora, Yasushi Nakazawa, Naoki Hasegawa, Tadashi Yoshida, Shu Wakino, Yoshiaki Takemoto and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2018 4:41

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  14. Content type: Case Report

    Pleuroperitoneal leak is an uncommon but significant complication of peritoneal dialysis. Although the exact pathogenesis of pleuroperitoneal communication remains unclear, the pressure gradient between the th...

    Authors: Yoshihiko Fujino, Noritaka Kawada, Katsukiyo Ito, Hiroshi Katsura, Hajime Maeda, Kensuke Mitsumoto and Takashi Uzu

    Citation: Renal Replacement Therapy 2018 4:40

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  15. Content type: Case Report

    High-dose methotrexate (HD-MTX) therapy has been used to treat a wide range of oncological malignancies. While the therapy can be tolerated with hydration, urine pH control, and leucovorin rescue therapy, HD-M...

    Authors: Mineaki Kitamura, Satoko Kitamura, Machiko Fujioka, Rena Kamijo, Shinya Sato, Yasushi Sawayama, Tadashi Uramatsu, Yoko Obata, Yasushi Mochizuki, Masaharu Nishikido, Hideki Sakai, Yasushi Miyazaki, Hiroshi Mukae and Tomoya Nishino

    Citation: Renal Replacement Therapy 2018 4:39

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  16. Content type: Case Report

    Hypereosinophilic syndrome (HES) consists of a group of disorders characterized by abnormal accumulation of eosinophils in the blood or peripheral tissues, independent of known secondary causes of eosinophilia...

    Authors: Eri Amano, Taro Horino, Osamu Ichii, Satoshi Inotani, Tatsuki Matsumoto, Kazu Hamada-Ode, Yoshiko Shimamura, Kosuke Inoue and Yoshio Terada

    Citation: Renal Replacement Therapy 2018 4:38

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  17. Content type: Research

    The definition and guideline of sepsis and septic shock were recently updated. The aim of this study is to evaluate the ability of Third Consensus Definitions of Sepsis and Septic Shock (Sepsis-3) to predict o...

    Authors: Maho Akiu, Tae Yamamoto, Mariko Miyazaki, Kimio Watanabe, Emi Fujikura, Masaaki Nakayama, Hiroshi Sato and Sadayoshi Ito

    Citation: Renal Replacement Therapy 2018 4:37

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  18. Content type: Case Report

    Refeeding syndrome is a potentially fatal electrolyte shift in patients with rapid feeding after low-calorie intake. Although the key to diagnosing refeeding syndrome is hypophosphatemia after feeding, renal d...

    Authors: Yoshihisa Miyamoto, Yoshifumi Hamasaki, Akihiko Matsumoto, Kent Doi and Masaomi Nangaku

    Citation: Renal Replacement Therapy 2018 4:35

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  19. Content type: Position Statement

    Acute kidney injury (AKI) is a syndrome which has a broad range of etiologic factors depending on different clinical settings. Because AKI has significant impacts on prognosis in any clinical settings, early d...

    Authors: Kent Doi, Osamu Nishida, Takashi Shigematsu, Tomohito Sadahiro, Noritomo Itami, Kunitoshi Iseki, Yukio Yuzawa, Hirokazu Okada, Daisuke Koya, Hideyasu Kiyomoto, Yugo Shibagaki, Kenichi Matsuda, Akihiko Kato, Terumasa Hayashi, Tomonari Ogawa, Tatsuo Tsukamoto…

    Citation: Renal Replacement Therapy 2018 4:36

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  20. Content type: Research

    Decreased physical activity in hemodialysis (HD) patients causes various structural, metabolic, and functional abnormalities due to uremic changes in skeletal muscles. Electrical stimulation (ES) of the lower ...

    Authors: Misa Miura, Aki Hirayama, Shigeru Oowada, Akihito Nishida, Chie Saito, Kunihiro Yamagata, Osamu Ito, Yo Hirayama and Masahiro Kohzuki

    Citation: Renal Replacement Therapy 2018 4:33

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  21. Content type: Research

    Polymethyl methacrylate (PMMA) membranes have the unique property of adsorption, which can remove medium- and large-weight molecular substances that cannot be removed by normal hemodialysis and hemodiafiltrati...

    Authors: Nobuko Uchiumi, Koji Sakuma, Sumihiko Sato, Yoshinaga Matsumoto, Hirotada Kobayashi, Koki Toriyabe, Katsumi Hayashi, Tadayuki Kawasaki, Takashi Watanabe, Ayumi Itohisa, Masanori Yokota, Katsumi Okazawa and Noriyoshi Murotani

    Citation: Renal Replacement Therapy 2018 4:32

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  22. Content type: Research

    Historically, cellulose-based materials have been used for manufacturing hemodialysis membranes and remain to date as the commonly used materials. Though cellulose triacetate (CTA) membrane originally has a ho...

    Authors: Konomi Togo, Masahito Yamamoto, Motoyuki Imai, Keiichi Akiyama and Akihiro C. Yamashita

    Citation: Renal Replacement Therapy 2018 4:29

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  23. Content type: Research

    Serum albumin is a marker of nourishment and inflammation. Although hypoalbuminemia in hemodialysis patients is reported as a risk factor for poor prognosis, few studies describe its effects on infectious dise...

    Authors: Shun Minatoguchi, Atsushi Nomura, Takahiro Imaizumi, Sho Sasaki, Takaya Ozeki, Daisuke Uchida, Hiroo Kawarazaki, Fumihiko Sasai, Keigo Tomita, Hideaki Shimizu and Yoshiro Fujita

    Citation: Renal Replacement Therapy 2018 4:30

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  24. Content type: Research

    We investigated whether serum uric acid (SUA) levels before kidney transplantation predict new-onset diabetes after kidney transplantation (NODAT) and compared SUA levels with known risk factors for NODAT by p...

    Authors: Kentaro Tanaka, Ken Sakai, Akifumi Kushiyama, Shigeko Hara, Masakazu Hattori, Yasushi Ohashi, Masaki Muramatsu, Takeshi Kawamura, Seiichiro Shishido and Atsushi Aikawa

    Citation: Renal Replacement Therapy 2018 4:28

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  25. Content type: Research

    Peripheral arterial disease (PAD) has much impact on mortality in hemodialysis (HD) patients. Ankle-brachial index (ABI) and skin perfusion pressure (SPP) are useful tools to detect PAD in HD patients. However...

    Authors: Kunihiro Ishioka, Takayasu Ohtake, Hidekazu Moriya, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Sumi Hidaka and Shuzo Kobayashi

    Citation: Renal Replacement Therapy 2018 4:27

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  26. Content type: Research

    Pruritus in patients undergoing hemodialysis reduces quality of life via insomnia and depression, and negatively affects prognosis. For diagnosing pruritus, selecting therapeutic strategies, and determining th...

    Authors: Naoko Takahashi, Taku Yoshizawa, Aiko Okubo, Junko Kumagai, Hideki Kawanishi, Shinichiro Tsuchiya, Misaki Moriishi, Takao Masaki and Toshiya Ebata

    Citation: Renal Replacement Therapy 2018 4:26

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  27. Content type: Case Report

    Tuberous sclerosis complex is an autosomal dominant genetic disorder that affects multiple organ systems and can result in tumors in the brain, skin, heart, and kidneys; it may also cause neurological symptoms...

    Authors: Akira Ashida, Hideki Matsumura, Yuko Fujii, Hyogo Nakakura, Akihiko Shirasu and Hiroshi Tamai

    Citation: Renal Replacement Therapy 2018 4:25

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  28. Content type: Research

    Low tongue pressure contributes to oral frailty. It is a condition in which the pressure between the tongue, palate, and food decreases due to a decrease in tongue muscle function. Low tongue pressure interfer...

    Authors: Yuka Kamijo, Eiichiro Kanda, Keisuke Ono, Keizo Maeda, Akane Yanai, Kazuya Honda, Ryuji Tsujimoto, Mai Yanagi, Yoshitaka Ishibashi and Masayuki Yoshida

    Citation: Renal Replacement Therapy 2018 4:23

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  29. Content type: Case Report

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disease among primary diseases in dialysis patients. Tolvaptan is known to improve increases in total kidney volume (TKV) in pa...

    Authors: Shuma Hirashio, Shigehiro Doi and Takao Masaki

    Citation: Renal Replacement Therapy 2018 4:24

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  30. Content type: Case Report

    Infection is the second leading cause of mortality in patients who undergo maintenance hemodialysis. In this population, impairment in both cellular and humoral immunity contributes to the increased incidence ...

    Authors: Shunsuke Yamada, Narihito Tatsumoto, Noriko Nakamura, Kosuke Masutani, Toshiro Maeda, Takanari Kitazono and Kazuhiko Tsuruya

    Citation: Renal Replacement Therapy 2018 4:22

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  31. Content type: Research

    Chronic kidney disease (CKD) is one of the main public health issues. It increases the morbidity and mortality of patients. Treatment includes multiple aspects such as dialysis and lifestyle modifications. The...

    Authors: Ibrahim Mousa, Raed Ataba, Khaled Al-ali, Abdulsalam Alkaiyat and Sa’ed H. Zyoud

    Citation: Renal Replacement Therapy 2018 4:21

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  32. Content type: Research

    Hemodialysis catheters are commonly used for vascular access in patients undergoing blood purification therapies. However, the sudden dysfunction of catheters represents a serious problem, and while we know th...

    Authors: Yoshimitsu Takahashi, Junichiro J. Kazama, Suguru Yamamoto, Takashi Oite and Ichiei Narita

    Citation: Renal Replacement Therapy 2018 4:20

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  33. Content type: Case Report

    Patients with end-stage renal failure may exhibit sarcopenia and protein-energy wasting (PEW). We report a case of improvement in physical function, muscle mass, and muscle strength by management of rehabilita...

    Authors: Chiharu Uno, Hidetaka Wakabayashi, Keisuke Maeda and Shinta Nishioka

    Citation: Renal Replacement Therapy 2018 4:18

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  34. Content type: Research

    Asymptomatic peripheral artery disease (PAD) increases the risk of mortality in non-hemodialysis patients. However, the association between asymptomatic PAD and mortality rate remains unclear in patients on he...

    Authors: Manae Harada, Ryota Matsuzawa, Naoyoshi Aoyama, Kaoru Uemura, Yoriko Horiguchi, Junko Yoneyama, Keika Hoshi, Kei Yoneki, Takaaki Watanabe, Takahiro Shimoda, Yasuo Takeuchi, Shokichi Naito, Atsushi Yoshida and Atsuhiko Matsunaga

    Citation: Renal Replacement Therapy 2018 4:17

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  35. Content type: Research

    l-carnitine is essential for lipid metabolism, and lack of l-carnitine intake and loss by treatments lead to carnitine depletion causing muscle weakness, anemia, and immune dysfunction. Carnitine depletion occurs...

    Authors: Takehiko Oami, Taku Oshima, Noriyuki Hattori, Ayako Teratani, Saori Honda, Toshihiko Yoshida and Shigeto Oda

    Citation: Renal Replacement Therapy 2018 4:13

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  36. Content type: Case Report

    TAFRO (thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal failure, and organomegaly) syndrome is a systemic inflammatory disorder and unique clinicopathological variant of idiopathic multicentric...

    Authors: Arata Hibi, Ken Mizuguchi, Akiko Yoneyama, Takahisa Kasugai, Keisuke Kamiya, Keisuke Kamiya, Chiharu Ito, Satoru Kominato, Toshiyuki Miura and Katsushi Koyama

    Citation: Renal Replacement Therapy 2018 4:16

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  37. Content type: Research

    All forms of shock, particularly septic shock, that involve insufficient blood supply to tissues to meet metabolic demands are main causes of morbidity and mortality worldwide and develop in one third of patie...

    Authors: Alexa Hollinger, Lukas Gantner, Franziska Jockers, Thomas Schweingruber, Katrin Ledergerber, Jonas Dominic Scheuzger, Markus Aschwanden, Michael Dickenmann, Johann Knotzer, Jasper van Bommel and Martin Siegemund

    Citation: Renal Replacement Therapy 2018 4:14

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  38. Content type: Position statement

    The annual survey of Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was conducted for 4380 dialysis facilities at the end of 2015, among which 4321 facilities (98.7%) responded. The response ...

    Authors: Ikuto Masakane, Masatomo Taniguchi, Shigeru Nakai, Kenji Tsuchida, Shunsuke Goto, Atsushi Wada, Satoshi Ogata, Takeshi Hasegawa, Takayuki Hamano, Norio Hanafusa, Junichi Hoshino, Jun Minakuchi and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2018 4:19

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  39. Content type: Position statement

    The necessity of purification of dialysis fluids has been discussed since the 1980s. The Japanese Society for Dialysis Therapy (JSDT) presented a standard for dialysis fluid purification in 1995 and revised th...

    Authors: Michio Mineshima, Hideki Kawanishi, Tomonobu Ase, Tadayuki Kawasaki, Tadashi Tomo and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2018 4:15

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  40. Content type: Research

    Chronic kidney disease is a major risk factor for dementia, but the influence of hemodialysis itself on the development of dementia remains unclear. We previously reported that non-diabetic patients on mainten...

    Authors: Shigeru Nakai, Kenji Wakai, Eiichiro Kanda, Kazunori Kawaguchi, Kazuyoshi Sakai and Nobuya Kitaguchi

    Citation: Renal Replacement Therapy 2018 4:12

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  41. Content type: Research

    This study aimed to explore the role of patient’s characteristic and haematological factors as predictive on the maturation of arteriovenous fistulae in patients who underwent vascular access surgery at the Ro...

    Authors: Muhammad A. Siddiqui, Suhel Ashraff, Derek Santos, Robert Rush, Thomas E. Carline and Zahid Raza

    Citation: Renal Replacement Therapy 2018 4:11

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  42. Content type: Research

    In Japan, the most commonly used hemofilters for patients with acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) are made of polysulfone membranes. The aim of this study was to...

    Authors: Hideto Yasuda, Kosuke Sekine, Takayuki Abe, Shinichiro Suzaki, Atsushi Katsumi, Naoshige Harada, Hidenori Higashi, Yuki Kishihara, Hidetaka Suzuki and Toru Takebayashi

    Citation: Renal Replacement Therapy 2018 4:6

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  43. Content type: Research

    In the patients with severe atherosclerotic renal artery stenosis (ARAS), the evaluation of long-term clinical outcome after percutaneous transluminal renal angioplasty (PTRA) has yet been insufficient. The ai...

    Authors: Yasuhiro Mochida, Takayasu Ohtake, Yusuke Miyashita, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Sumi Hidaka, Shigeru Saito and Shuzo Kobayashi

    Citation: Renal Replacement Therapy 2018 4:5

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  44. Content type: Research

    To cope with the increasing number of patients on long-term hemodialysis (HD), especially those with diabetic nephropathy, we designed a fully automated HD system to decrease staff workload and hence human err...

    Authors: Takashi Shigematsu, Jun Minakuchi, Satoshi Funakoshi, Junichiro Hashiguchi, Hiroshi Yoshimoto, Kyoko Ito, Takuya Ban and Tetsunosuke Kunitomo

    Citation: Renal Replacement Therapy 2018 4:9

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  45. Content type: Research

    Patients undergoing hemodialysis (HD) have difficulty performing activities of daily living (ADL) compared to healthy people. ADL difficulty is an early predictor of loss of independence and mortality in older...

    Authors: Takaaki Watanabe, Toshiki Kutsuna, Kei Yoneki, Manae Harada, Takahiro Shimoda, Yusuke Matsunaga, Norio Murayama, Ryota Matsuzawa, Yasuo Takeuchi, Atsushi Yoshida and Atsuhiko Matsunaga

    Citation: Renal Replacement Therapy 2018 4:8

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