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  1. Peritoneal dialysis (PD)-associated peritonitis caused by Sphingomonas paucimobilis (S. paucimobilis) is very rare, and most of the characteristics of such cases are still unknown.

    Authors: Chiharu Kinoshita, Koichi Matsuda, Yumiko Kawai, Takayuki Hagiwara and Akane Okada

    Citation: Renal Replacement Therapy 2021 7:64

    Content type: Case Report

    Published on:

  2. Hemodialysis (HD) patients are at a high risk of falls and fractures. The amount of physical activity (PA) they perform may be limited by psychosomatic factors associated with fear of falling, leading to frail...

    Authors: Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Sumiyo Nitami and Ichiei Narita

    Citation: Renal Replacement Therapy 2021 7:63

    Content type: Research

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  3. Hemodialysis is a medical technology implemented for various renal diseases and has a significant budget impact in Japan. Hemodialysis also affects health-related quality of life, as it interferes with daily l...

    Authors: Shinichi Noto, Masashi Miyazaki, Hidemi Takeuchi and Shinya Saito

    Citation: Renal Replacement Therapy 2021 7:62

    Content type: Research

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  4. The appropriate dosing of imipenem for critically ill AKI patients undergoing CRRT remains scarce.

    Authors: Dhakrit Rungkitwattanakul, Taniya Charoensareerat, Pathakorn Kerdnimith, Nutsinee Kosumwisaisakul, Piyakamol Teeranaew, Apinya Boonpeng, Sutthiporn Pattharachayakul, Nattachai Srisawat and Weerachai Chaijamorn

    Citation: Renal Replacement Therapy 2021 7:61

    Content type: Research

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  5. Removal of anti-blood group antibodies is important for successful ABO-incompatible kidney transplantation (ABOi-KTx). Double-filtration plasmapheresis (DFPP) using albumin solution removes antibodies effectiv...

    Authors: Daiki Iwami, Takenao Matsumoto, Kota Ono, Kiyohiko Hotta, Minoru Ota, Yuki Chiba, Hajime Sasaki, Takayuki Hirose, Haruka Higuchi, Yusuke Takada, Naoya Iwahara, Sachiyo Murai and Nobuo Shinohara

    Citation: Renal Replacement Therapy 2021 7:60

    Content type: Research

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  6. The Japanese Association of Dialysis Physicians, the Japanese Society for Dialysis Therapy, and the Japanese Society of Nephrology jointly established COVID-19 Task Force Committee and began surveying the numb...

    Authors: Kan Kikuchi, Masaomi Nangaku, Munekazu Ryuzaki, Tomoyuki Yamakawa, Oota Yoshihiro, Norio Hanafusa, Ken Sakai, Yoshihiko Kanno, Ryoichi Ando, Toshio Shinoda, Hidetomo Nakamoto and Tadao Akizawa

    Citation: Renal Replacement Therapy 2021 7:59

    Content type: Research

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  7. Enhanced oxidative stress is involved with fatigue in hemodialysis (HD) patients. Molecular hydrogen (H2) could improve the redox status. Thus, the study examines whether HD solution rendered by electrolyzed wate...

    Authors: Yoshihiro Tsujimoto, Daisuke Kuratsune, Shigeru Kabayama, Mariko Miyazaki, Yasuyoshi Watanabe, Yoshiki Nishizawa and Masaaki Nakayama

    Citation: Renal Replacement Therapy 2021 7:58

    Content type: Research

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  8. Though treatment of anemia in chronic kidney disease (CKD) patients has been improved remarkably by erythropoiesis-stimulating agents (ESA), hypo-responsiveness to ESA poses a persistent problem in a subgroup ...

    Authors: Akira Ishimitsu, Hiroshi Satonaka, Masahito Furuichi, Yoshiki Murayama, Akihiro Tojo and Toshihiko Ishimitsu

    Citation: Renal Replacement Therapy 2021 7:57

    Content type: Research

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  9. In Japan, forgoing life-sustaining treatment to respect the will of patients at the terminal stage is not stipulated by law. According to the Guidelines for the Decision-Making Process in Terminal-Stage Health...

    Authors: Kazuyoshi Okada, Ken Tsuchiya, Ken Sakai, Takahiro Kuragano, Akiko Uchida, Kazuhiko Tsuruya, Tadashi Tomo, Chieko Hamada, Masafumi Fukagawa, Yoshindo Kawaguchi, Yuzo Watanabe, Kaoruko Aita, Yoshitatsu Ogawa, Junji Uchino, Hirokazu Okada, Yutaka Koda…

    Citation: Renal Replacement Therapy 2021 7:56

    Content type: Position statement

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  10. The prevalence of chronic kidney disease (CKD) has been on the rise worldwide. Epidemiological studies performed primarily in Central America and South Asia have reported high prevalence of CKD among young and...

    Authors: Kei Nagai

    Citation: Renal Replacement Therapy 2021 7:55

    Content type: Review

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  11. Kidney transplantation has established itself as the most appropriate mode of renal replacement therapy for the majority with end-stage kidney disease. Although at present this is applicable for children as we...

    Authors: Thilina Gunawardena, Hemant Sharma, Ajay Kumar Sharma and Sanjay Mehra

    Citation: Renal Replacement Therapy 2021 7:54

    Content type: Review

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  12. Cambodia detected its first case of COVID-19 just 3 days before WHO declared that the outbreak constituted as PHEIC. As of February 15, 2021, and after two major outbreaks, only 479 cases had been reported, 39...

    Authors: Tam Nov, Toru Hyodo, Yukie Kitajima, Kenichi Kokubo, Toshihide Naganuma, Haruki Wakai, Akihiro Yamashita, Elin Phon and Hideki Kawanishi

    Citation: Renal Replacement Therapy 2021 7:53

    Content type: Review

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  13. Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by hypotension, hemoconcentration, and hypoalbuminemia associated with increased capillary endothelium permeability. Patients with a chr...

    Authors: Keisuke Sunohara, Rie Shimizu, Kazushi Yasuda, Akiko Owaki, Hiroshi Nagaya, Tomohiro Kajiguchi and Shinichiro Inaba

    Citation: Renal Replacement Therapy 2021 7:52

    Content type: Case Report

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  14. Evidence concerning online hemodiafiltration (ol-HDF) includes increased uremic toxin removal, prevention of dialysis-related hypotension, improved survival, and recovery of dialysis-related uncertain symptoms...

    Authors: Hideki Kawanishi

    Citation: Renal Replacement Therapy 2021 7:51

    Content type: Review

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  15. Salazosulfapyridine is a generally safe drug often used to treat rheumatoid arthritis and ulcerative colitis. However, agranulocytosis is a rare but serious adverse effect of this drug. To date, there have bee...

    Authors: Takeshi Iida, Kimihiko Nakata, Masayoshi Fukui and Masaru Umeda

    Citation: Renal Replacement Therapy 2021 7:50

    Content type: Case Report

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  16. In Japan, only less than 3% of patients undergoing maintenance dialysis select peritoneal dialysis (PD) as the mode of renal replacement therapy. Half of patients undergoing PD use a cycler for automated PD (A...

    Authors: Hisako Yoshida and Kazuhiko Tsuruya

    Citation: Renal Replacement Therapy 2021 7:49

    Content type: Research

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  17. Whether progressive mild to moderate aortic stenosis in hemodialysis patients influences their prognosis has not been elucidated. This prospective cohort study explored whether progressive aortic stenosis pred...

    Authors: Yoriko Horiguchi, Kaoru Uemura, Naoyoshi Aoyama, Shinichi Nakajima, Tomoki Asai, Sachiko Motohashi, Manae Harada, Maoko Ida and Atsushi Yoshida

    Citation: Renal Replacement Therapy 2021 7:48

    Content type: Research

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  18. Sepsis is associated with life-threatening organ dysfunction caused by a dysregulated host response to infection. However, no specific therapy has been shown to improve mortality in patients with sepsis. We co...

    Authors: Kasumi Satoh, Kyoko Nomura, Hajime Nakae, Daisuke Kudo, Shigeki Kushimoto, Masatsugu Hasegawa, Fumihito Ito, Satoshi Yamanouchi, Hiroyuki Honda, Kohkichi Andoh, Hajime Furukawa, Yasuo Yamada, Yuta Tsujimoto and Manabu Okuyama

    Citation: Renal Replacement Therapy 2021 7:47

    Content type: Research

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  19. This article is a duplicated publication from the Japanese version of “2019 JSDT Guidelines for Peritoneal Dialysis” with permission from the Japanese Society for Dialysis Therapy (JSDT). This clinical practic...

    Authors: Munekazu Ryuzaki, Yasuhiko Ito, Hidetomo Nakamoto, Yuichi Ishikawa, Noritomo Itami, Minoru Ito, Atsushi Ueda, Yoshie Kanazawa, Hideki Kawanishi, Yoshihiko Kanno, Hitoshi Sugiyama, Kazuhiko Tsuruya, Hiroyuki Terawaki, Tadashi Tomo, Mizuya Fukasawa, Akihiro C. Yamashita…

    Citation: Renal Replacement Therapy 2021 7:46

    Content type: Position statement

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  20. Vitamin D deficiency is often observed in patients undergoing maintenance hemodialysis and is associated with significantly increased risk of overall mortality. Despite reports of poor nutrition/intake, vitami...

    Authors: Keisuke Yoshida, Tomoki Yonaha, Masayuki Yamanouchi, Hirofumi Sumi, Yasuhiro Taki, Yuhei Otobe, Minoru Miyashita, Rina Hachisuka, Wei Han, Yugo Shibagaki and Naoto Tominaga

    Citation: Renal Replacement Therapy 2021 7:45

    Content type: Research

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  21. Whether uric acid (UA)-lowering therapy (ULT) is effective in reducing the progression of renal dysfunction in patients with chronic kidney disease (CKD) remains controversial. Since several advances have been...

    Authors: Yukio Maruyama, Takanori Kumagai, Naoki Sugano, Shigetaka Yoshida, Kimiyoshi Ichida and Shunya Uchida

    Citation: Renal Replacement Therapy 2021 7:44

    Content type: Research

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  22. In May and June 2020, an outbreak of methanol poisoning arose in the southwest United States linked to ingestion of contaminated hand sanitizer imported during the coronavirus disease 2019 pandemic, ultimately...

    Authors: Alisa C. Illescas, Christos P. Argyropoulos, Sara A. Combs, Saeed K. Shaffi, Zhi Q. Xu, Michael A. Aragon and J. Pedro Teixeira

    Citation: Renal Replacement Therapy 2021 7:43

    Content type: Case Report

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  23. According to the annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) conducted at the end of 2018, there were a total of 339,841 patients receiving dialysis (hereinafter, dial...

    Authors: Kosaku Nitta, Shigeru Nakai, Ikuto Masakane, Norio Hanafusa, Shunsuke Goto, Masatomo Taniguchi, Takeshi Hasegawa, Atsushi Wada, Takayuki Hamano, Junichi Hoshino, Nobuhiko Joki, Keichi Yamamoto, Kenichiro Miura, Masanori Abe and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2021 7:41

    Content type: Position statement

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  24. Approximately 10 years have passed since the Peritoneal Dialysis Guidelines were formulated in 2009. Much evidence has been reported during the succeeding years, which were not taken into consideration in the ...

    Authors: Yasuhiko Ito, Munekazu Ryuzaki, Hitoshi Sugiyama, Tadashi Tomo, Akihiro C. Yamashita, Yuichi Ishikawa, Atsushi Ueda, Yoshie Kanazawa, Yoshihiko Kanno, Noritomo Itami, Minoru Ito, Hideki Kawanishi, Masaaki Nakayama, Kazuhiko Tsuruya, Hideki Yokoi, Mizuya Fukasawa…

    Citation: Renal Replacement Therapy 2021 7:40

    Content type: Position statement

    Published on:

  25. The Japanese population is aging quickly. New methods of supporting peritoneal dialysis (PD) for elderly patients are essential if we are to increase the number of such patients.

    Authors: Kohsuke Terada, Yorito Yanagida, Tomohiro Yan, Toshiki Funakoshi, Akio Hirama, Tetsuya Kashiwagi and Yukinao Sakai

    Citation: Renal Replacement Therapy 2021 7:39

    Content type: Research

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  26. A novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined the impact of E-HD on changes i...

    Authors: Hidehisa Satta, Tamio Iwamoto, Yuki Kawai, Naoaki Koguchi, Kazuhiko Shibata, Nobuteru Kobayashi, Mariko Yoshida and Masaaki Nakayama

    Citation: Renal Replacement Therapy 2021 7:37

    Content type: Research

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  27. Low physical fitness is often found in patients undergoing hemodialysis. It may be possible that the recovery of impaired motor function with rehabilitative training might be affected when the patient is on he...

    Authors: Takeki Ishida, Kenichi Kono, Yuusuke Nishida and Masahiro Yoshida

    Citation: Renal Replacement Therapy 2021 7:35

    Content type: Research

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  28. The risk of adverse events associated with peritoneal dialysis (PD) in elderly patients has not been thoroughly investigated. The purpose of this study was to assess the association between physical function a...

    Authors: Hiroki Yabe, Yuto Imoto, Ayaka Onoyama, Sayaka Ito, Kenichi Kono, Yoshifumi Moriyama, Keiko Okada, Hirotake Kasuga and Yasuhiko Ito

    Citation: Renal Replacement Therapy 2021 7:34

    Content type: Research

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  29. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect the kidney and the presence of chronic kidney disease (CKD) constitutes a higher risk of negative prognosis. SARS-CoV-2 main sequelae in ...

    Authors: Heitor S. Ribeiro, Amanda E. Rodrigues, Jennifer Cantuária, Antônio Inda-Filho and Paul N. Bennett

    Citation: Renal Replacement Therapy 2021 7:33

    Content type: Review

    Published on:

  30. Despite the fact that the fundamental characteristics of coronavirus disease-2019 (COVID-19) are respiratory manifestations, multi-organ failure including the kidney has been documented. There are no clear com...

    Authors: Enass E. El-Sayed, Abdou K. Allayeh, Amany A. Salem, Sheren M. Omar, Salwa M. Zaghlol, Hala M. Abd-Elmaguid, Mohammed M. Abdul-Ghaffar and Magdy M. ElSharkawy

    Citation: Renal Replacement Therapy 2021 7:32

    Content type: Research

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  31. Malnutrition that is associated with inflammation is a key factor of poor outcome in chronic hemodialysis patients, especially in older dialysis patients. Polymethyl methacrylate (PMMA) membrane has been repor...

    Authors: Ikuto Masakane, Ichiro Yamaguchi, Yuji Matsumoto, Ken Ataka, Yuta Oyama, Michio Nagaoka, Yasushi Matsushita, Tomoko Teramura, Koji Seino, Hiroyuki Amano and Ai Kobayashi

    Citation: Renal Replacement Therapy 2021 7:31

    Content type: Research

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  32. Patients with chronic kidney disease often suffer from cardiovascular disease, and vascular calcification has been identified as one of the risk factors for cardiovascular disease. We aimed to examine the effe...

    Authors: Kentaro Nakai, Shutaro Yamamoto, Megumi Inoue, Chiaki Kohara, Tomoya Shukuri, Kentaro Motoyama and Koji Mitsuiki

    Citation: Renal Replacement Therapy 2021 7:30

    Content type: Research

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  33. In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary to improve the biocompatibility of peritoneal dialysis fluids (PDFs). The novel bicarbonate/lactate-buffered ...

    Authors: Hiromichi Ueno, Tetsu Miyamoto, Hiroyuki Morimoto, Kenya Sanada, Ikutaro Furuno, Kazutoshi Nakazono, Emi Hasegawa, Akihiro Kuma, Yasushi Oginosawa, Yuki Tsuda, Masaru Araki, Masahito Tamura, Yoichi Ueta, Yutaka Otsuji and Masaharu Kataoka

    Citation: Renal Replacement Therapy 2021 7:29

    Content type: Research

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  34. The prevalence of end-stage kidney disease (ESKD) is growing worldwide; the survival of these patients requires renal replacement therapy (RRT, a complex and costly treatment). Over 20% of the patients that st...

    Authors: Isabella Vanorio-Vega, Panayotis Constantinou, Philippe Tuppin and Cécile Couchoud

    Citation: Renal Replacement Therapy 2021 7:28

    Content type: Review

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  35. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic affecting a variety of medical treatments, including hemodialysis. This...

    Authors: Yuka Sugawara, Masao Iwagami, Kan Kikuchi, Yoko Yoshida, Ryoichi Ando, Toshio Shinoda, Munekazu Ryuzaki, Hidetomo Nakamoto, Ken Sakai, Norio Hanafusa, Naoki Kashihara and Masaomi Nangaku

    Citation: Renal Replacement Therapy 2021 7:27

    Content type: Position statement

    Published on:

  36. Low-ionized magnesium and high-ionized calcium levels are associated with increased cardiovascular mortality in patients undergoing dialysis. We examined the effects of the dilution method, substitution volume...

    Authors: Yusaku Tanaka, Hisato Shima, Ryosuke Hatonari, Daisuke Okada, Hiroyuki Michiwaki, Seiichiro Wariishi, Tomohiro Tao and Jun Minakuchi

    Citation: Renal Replacement Therapy 2021 7:26

    Content type: Research

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  37. Peritoneal dialysis (PD)-related peritonitis risk factors can be categorized as modifiable and uncorrectable. We aimed to identify modifiable risk factors for PD-related peritonitis in our facility to prevent ...

    Authors: Shigeki Kojima, Shohei Yamada, Rie Fujishima, Kenichiro Koitabashi, Yugo Shibagaki and Tsutomu Sakurada

    Citation: Renal Replacement Therapy 2021 7:25

    Content type: Research

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  38. Hemodialysis-associated pruritus (HAP) is a serious complication that occurs in 60–80% of hemodialysis patients, which not only decreases quality of life but also worsens prognosis. We have developed a treatme...

    Authors: Naoko Takahashi, Taku Yoshizawa, Junko Kumagai, Hideki Kawanishi, Shinichiro Tsuchiya, Misaki Moriishi and Takao Masaki

    Citation: Renal Replacement Therapy 2021 7:24

    Content type: Research

    Published on:

  39. According to the annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) conducted at the end of 2018, a total of 339,841 patients were receiving dialysis (hereinafter, dialysis p...

    Authors: Kosaku Nitta, Shigeru Nakai, Ikuto Masakane, Norio Hanafusa, Shunsuke Goto, Masatomo Taniguchi, Takeshi Hasegawa, Atsushi Wada, Takayuki Hamano, Junichi Hoshino, Nobuhiko Joki, Keichi Yamamoto, Kenichiro Miura, Masanori Abe and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2021 7:22

    Content type: Research

    Published on:

  40. Intradialytic exercises are recommended to be available as a treatment for enhancing physical functioning. However, there have been few reports which evaluated the results of long-term mild intradialytic exerc...

    Authors: Masahiro Kato, Masanori Shibata, Kazuaki Asai, Kumi Harada, Isao Ito, Hisae Tawada, Kojiro Nagai and Shinkichi Taniguchi

    Citation: Renal Replacement Therapy 2021 7:21

    Content type: Research

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  41. In the development of medical devices usability is an important aspect standing alongside performance and safety. Peritoneal dialysis (PD) can be provided by use of automated PD (APD), assisted by a cycler per...

    Authors: Thore Reitz, Stephanie Schwenke, Sebastian Hölzle and Adelheid Gauly

    Citation: Renal Replacement Therapy 2021 7:20

    Content type: Research

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  42. During the outbreak of new coronavirus pneumonia, many hospitals in China became the designated hospitals for the treatment of new coronavirus pneumonia. The goal was to develop rapid and effective prevention ...

    Authors: Jinmei Yin, Jun Yin, Zhiwu Tian, Peiqiu Li and Xiaoqiu Chen

    Citation: Renal Replacement Therapy 2021 7:19

    Content type: Research

    Published on:

  43. Intradialytic hypotension (IDH) is one of the most frequent complications of hemodialysis. IDH alters a patient’s quality of life and has a strong association with mortality. IDH mainly occurs when ultrafiltra...

    Authors: Yumi Aoyama, Katsuya Kajimoto, Maiko Hori, Shigeru Otsubo and Kosaku Nitta

    Citation: Renal Replacement Therapy 2021 7:18

    Content type: Research

    Published on:

  44. Adrenal insufficiency causes abnormal subjective symptoms such as general fatigue, signs such as hypotension, and abnormalities such as hypoglycemia and leads to poor prognosis. However, all these are also obs...

    Authors: Naro Ohashi, Yukitoshi Sakao, Taichi Sato, Sayaka Ishigaki, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato and Hideo Yasuda

    Citation: Renal Replacement Therapy 2021 7:17

    Content type: Research

    Published on:

  45. Some types of antihypertensive drugs may have pleiotropic effects in patients with chronic kidney disease (CKD). However, whether triple combination therapy with angiotensin II receptor blockers (ARBs), calciu...

    Authors: Sakuya Ito, Yosuke Nakayama, Goh Kodama, Kanji Ota, Kensei Taguchi, Yusuke Kaida, Sho-ichi Yamagishi and Kei Fukami

    Citation: Renal Replacement Therapy 2021 7:16

    Content type: Research

    Published on:

  46. Multiple organ dysfunction syndrome is the leading cause of death in pediatric intensive care units and can be very critical when combined with shock and disseminated intravascular coagulation (DIC). Currently...

    Authors: Hiroyuki Nagafuchi, Hiroyuki Shimizu, Kaori Yamada, Kenta Shono and Tetsuya Ogawa

    Citation: Renal Replacement Therapy 2021 7:15

    Content type: Research

    Published on:

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