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  1. Content type: Case Report

    TAFRO (thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal failure, and organomegaly) syndrome is a systemic inflammatory disorder and unique clinicopathological variant of idiopathic multicentric...

    Authors: Arata Hibi, Ken Mizuguchi, Akiko Yoneyama, Takahisa Kasugai, Keisuke Kamiya, Keisuke Kamiya, Chiharu Ito, Satoru Kominato, Toshiyuki Miura and Katsushi Koyama

    Citation: Renal Replacement Therapy 2018 4:16

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  2. Content type: Position statement

    The annual survey of Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was conducted for 4380 dialysis facilities at the end of 2015, among which 4321 facilities (98.7%) responded. The response ...

    Authors: Ikuto Masakane, Masatomo Taniguchi, Shigeru Nakai, Kenji Tsuchida, Shunsuke Goto, Atsushi Wada, Satoshi Ogata, Takeshi Hasegawa, Takayuki Hamano, Norio Hanafusa, Junichi Hoshino, Jun Minakuchi and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2018 4:19

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  3. Content type: Research

    All forms of shock, particularly septic shock, that involve insufficient blood supply to tissues to meet metabolic demands are main causes of morbidity and mortality worldwide and develop in one third of patie...

    Authors: Alexa Hollinger, Lukas Gantner, Franziska Jockers, Thomas Schweingruber, Katrin Ledergerber, Jonas Dominic Scheuzger, Markus Aschwanden, Michael Dickenmann, Johann Knotzer, Jasper van Bommel and Martin Siegemund

    Citation: Renal Replacement Therapy 2018 4:14

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  4. Content type: Position statement

    The necessity of purification of dialysis fluids has been discussed since the 1980s. The Japanese Society for Dialysis Therapy (JSDT) presented a standard for dialysis fluid purification in 1995 and revised th...

    Authors: Michio Mineshima, Hideki Kawanishi, Tomonobu Ase, Tadayuki Kawasaki, Tadashi Tomo and Hidetomo Nakamoto

    Citation: Renal Replacement Therapy 2018 4:15

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  5. Content type: Research

    Chronic kidney disease is a major risk factor for dementia, but the influence of hemodialysis itself on the development of dementia remains unclear. We previously reported that non-diabetic patients on mainten...

    Authors: Shigeru Nakai, Kenji Wakai, Eiichiro Kanda, Kazunori Kawaguchi, Kazuyoshi Sakai and Nobuya Kitaguchi

    Citation: Renal Replacement Therapy 2018 4:12

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  6. Content type: Research

    This study aimed to explore the role of patient’s characteristic and haematological factors as predictive on the maturation of arteriovenous fistulae in patients who underwent vascular access surgery at the Ro...

    Authors: Muhammad A. Siddiqui, Suhel Ashraff, Derek Santos, Robert Rush, Thomas E. Carline and Zahid Raza

    Citation: Renal Replacement Therapy 2018 4:11

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  7. Content type: Research

    In Japan, the most commonly used hemofilters for patients with acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) are made of polysulfone membranes. The aim of this study was to...

    Authors: Hideto Yasuda, Kosuke Sekine, Takayuki Abe, Shinichiro Suzaki, Atsushi Katsumi, Naoshige Harada, Hidenori Higashi, Yuki Kishihara, Hidetaka Suzuki and Toru Takebayashi

    Citation: Renal Replacement Therapy 2018 4:6

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  8. Content type: Research

    In the patients with severe atherosclerotic renal artery stenosis (ARAS), the evaluation of long-term clinical outcome after percutaneous transluminal renal angioplasty (PTRA) has yet been insufficient. The ai...

    Authors: Yasuhiro Mochida, Takayasu Ohtake, Yusuke Miyashita, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Sumi Hidaka, Shigeru Saito and Shuzo Kobayashi

    Citation: Renal Replacement Therapy 2018 4:5

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  9. Content type: Research

    To cope with the increasing number of patients on long-term hemodialysis (HD), especially those with diabetic nephropathy, we designed a fully automated HD system to decrease staff workload and hence human err...

    Authors: Takashi Shigematsu, Jun Minakuchi, Satoshi Funakoshi, Junichiro Hashiguchi, Hiroshi Yoshimoto, Kyoko Ito, Takuya Ban and Tetsunosuke Kunitomo

    Citation: Renal Replacement Therapy 2018 4:9

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  10. Content type: Research

    Patients undergoing hemodialysis (HD) have difficulty performing activities of daily living (ADL) compared to healthy people. ADL difficulty is an early predictor of loss of independence and mortality in older...

    Authors: Takaaki Watanabe, Toshiki Kutsuna, Kei Yoneki, Manae Harada, Takahiro Shimoda, Yusuke Matsunaga, Norio Murayama, Ryota Matsuzawa, Yasuo Takeuchi, Atsushi Yoshida and Atsuhiko Matsunaga

    Citation: Renal Replacement Therapy 2018 4:8

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  11. Content type: Review

    Peritoneal dialysis (PD)-related infection encompasses PD-related peritonitis and catheter-related infections, and the latter is used as the collective term to describe exit site infection (ESI) and tunnel inf...

    Authors: Cheuk Chun Szeto

    Citation: Renal Replacement Therapy 2018 4:7

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  12. Content type: Research

    The management of renal anemia in the pre-dialysis period has been remarkably improved by long-acting erythropoiesis-stimulating agents (ESA). However, many incident dialysis patients cannot achieve target hem...

    Authors: Shinya Kawamoto, Yu Kaneko, Hideo Misawa, Katsuhiro Nagahori, Atsushi Kitazawa, Atsunori Yoshino and Tetsuro Takeda

    Citation: Renal Replacement Therapy 2018 4:4

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  13. Content type: Research

    Chronic kidney disease (CKD) is an important global health challenge with increasing burden worldwide. CKD and acute kidney injury (AKI) may require renal replacement therapy (RRT) at some stages of the diseas...

    Authors: E. K. Tannor, Y. A. Awuku, V. Boima and S. Antwi

    Citation: Renal Replacement Therapy 2018 4:3

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  14. Content type: Case Report

    Purple color of urine is alarming and may indicate a serious underlying pathology. Purple discoloration of the urinary catheter bag is uncommon and is caused by urinary tract infection with certain organisms.

    Authors: Ankit Kayal, Shashanka Dhanuka, Bibhas Chandra Mukhopadhyay, Tapan Kumar Mandal and Charu Lata Bansal

    Citation: Renal Replacement Therapy 2017 3:52

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  15. Content type: Research

    Nutritional therapy and exercise training (ET) are important interventions for hemodialysis patients. We investigated the status of nutritional therapy and ET provided at hemodialysis facilities across Japan.

    Authors: Satoko Sakurai, Norio Hanafusa, Hideki Kato, Shinji Iizaka, Ryoko Murayama and Masaomi Nangaku

    Citation: Renal Replacement Therapy 2017 3:60

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  16. Content type: Case Report

    In the present report case, we show a peritonitis infection in a continuous ambulatory peritoneal dialysis (CAPD) patient in Colombia. We isolated Rhodococcus equi in the peritoneal fluid culture. Rhodococcus equ...

    Authors: José Lucas Daza, Yaroslad De La Cruz, Jesús Morales, Carolina Molina, Mauricio Duque, Ingrid Prieto and Victoria Ballen

    Citation: Renal Replacement Therapy 2017 3:59

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  17. Content type: Research

    Intradialytic hypotension (IDH) is a common clinical manifestation associated with poor prognosis in hemodialysis (HD) patients. HD patients who suffer from diabetic nephropathy (DN) are increasing and diabete...

    Authors: Kenji Tsuchida, Hirofumi Hashimoto, Kazuhiko Kawahara, Ikuro Hayashi, Yoshio Fukata, Munenori Kashiwagi, Akihiro C. Yamashita, Michio Mineshima, Tadashi Tomo, Ikuto Masakane, Yoshiaki Takemoto, Hideki Kawanishi, Kojiro Nagai and Jun Minakuchi

    Citation: Renal Replacement Therapy 2017 3:58

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  18. Content type: Research

    Carnitine is reported to improve insulin resistance and reduce oxidative stress. Hyperglycemia and increased oxidative stress are well known to promote the production of advanced glycation end products (AGEs) ...

    Authors: Yumi Kamada, Takashi Masuda, Kazuhiko Kotani, Shinya Tanaka, Takeshi Nakamura, Nobuaki Hamazaki, Yoko Itoh, Ibuki Moriguchi, Naoyuki Kobayashi, Michihito Okubo, Kazuhiro Takeuchi, Shokichi Naito and Yasuo Takeuchi

    Citation: Renal Replacement Therapy 2017 3:57

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  19. Content type: Research

    The reported prevalence rate of depressive symptoms in hemodialysis patients is 40%. Although appropriate management of these symptoms is important, they remain under-recognized and under-treated in hemodialys...

    Authors: Takahiro Shimoda, Ryota Matsuzawa, Keika Hoshi, Kei Yoneki, Manae Harada, Takaaki Watanabe and Atsuhiko Matsunaga

    Citation: Renal Replacement Therapy 2017 3:56

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  20. Content type: Research

    Nalfurafine hydrochloride (“nalfurafine”), the world’s first selective oral κ-receptor agonist for improving pruritus, is approved in Japan for the treatment of pruritus resistant to existing treatments in hem...

    Authors: Hidetomo Nakamoto, Takanori Oh, Masahiro Shimamura, Eiji Iida and Sadanobu Moritake

    Citation: Renal Replacement Therapy 2017 3:51

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  21. Content type: Research

    A lot of risk factors for mortality have been proposed in hemodialysis patients. However, most of the findings were derived from the analyses using all of the hemodialysis patients. What we really want to know...

    Authors: Kojiro Nagai, Sayo Ueda, Kenji Tsuchida, Toshio Doi and Jun Minakuchi

    Citation: Renal Replacement Therapy 2017 3:55

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  22. Content type: Research

    The inferior vena cava (IVC) dimensions represent the right ventricular preload, whereas the peak early mitral inflow wave velocity (peak E-velocity) represents the left ventricular preload. On the other hand,...

    Authors: Kazuo Kimura, Katsuya Kajimoto, Shigeru Otsubo, Takashi Akiba and Kosaku Nitta

    Citation: Renal Replacement Therapy 2017 3:54

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  23. Content type: Case Report

    Patients with end-stage renal disease are in an immune-compromised state, with infection being the most common cause of mortality among those undergoing dialysis.

    Authors: Manabu Hayata, Junji Yamashita, Kentaro Tokunaga, Masashi Ejima, Katsuyuki Sagishima, Shigeki Nakagawa, Daisuke Hashimoto, Hideo Baba, Kosuke Maruyama, Yu Kohrogi, Teruhiko Mizumoto, Masashi Mukoyama and Hidenobu Kamohara

    Citation: Renal Replacement Therapy 2017 3:53

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  24. Content type: Case Report

    Methotrexate (MTX), a folic acid antimetabolite, is administered at a high dose for the treatment of diseases such as leukemia and malignant lymphoma. Often, an effort is made to reduce the adverse effects of ...

    Authors: Emi Fujikura, Maho Akiu, Kenichiro Miyauchi, Mai Yoshida, Satoshi Aoki, Tae Yamamoto, Kaori Narumi, Noriko Yanagisawa, Takashi Nakamichi, Mariko Miyazaki, Hiroshi Sato and Sadayoshi Ito

    Citation: Renal Replacement Therapy 2017 3:48

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  25. Content type: Research

    How residual kidney function (RKF) functions in the prevention of anemia in peritoneal dialysis (PD) patients is unclear. In this study, we investigated the association between RKF and hemoglobin (Hb) level.

    Authors: Kazuhiko Tsuruya, Kumiko Torisu, Hisako Yoshida, Shunsuke Yamada, Shigeru Tanaka, Akihiro Tsuchimoto, Masahiro Eriguchi, Kiichiro Fujisaki, Kosuke Masutani and Takanari Kitazono

    Citation: Renal Replacement Therapy 2017 3:47

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  26. Content type: Case Report

    Trimethoprim–sulfamethoxazole (TMP/SMX) is an essential antimicrobial agent for treating pneumocystis pneumonia (PCP). Furthermore, the risk of hypoglycemia is increased with the co-administration of sulfonylu...

    Authors: Arata Hibi, Yusuke Kuga, Chiharu Ito, Toshiyuki Miura, Satoru Kominato, Keisuke Kamiya, Keisuke Kamiya, Takahisa Kasugai and Katsushi Koyama

    Citation: Renal Replacement Therapy 2017 3:45

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  27. Content type: Research

    The treatment of Kawasaki disease is controversial when intravenous immunoglobulin therapy fails, although it typically relies on combinations of prednisolone, infliximab, cyclosporine, and plasma exchange the...

    Authors: Yusuke Kaida, Takatoshi Kambe, Shintaro Kishimoto, Yusuke Koteda, Kenji Suda, Ryo Yamamoto, Tetsurou Imai, Takuma Hazama, Yoshimi Takamiya, Ryo Shibata, Hidemi Nishida, Seiya Okuda and Kei Fukami

    Citation: Renal Replacement Therapy 2017 3:50

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  28. Content type: Research

    Secondary hyperparathyroidism (SHPT) is associated with higher cardiovascular risk and mortality in patients undergoing dialysis. Cinacalcet hydrochloride (CH), which has been clinically available in Japan sin...

    Authors: Akiko Takeshima, Hiroaki Ogata, Yoshiyuki Kadokura, Yoshihiro Yamada, Kei Asakura, Tadashi Kato, Yoshinori Saito, Kantaro Matsuzaka, Go Takahashi, Masanori Kato, Masahiro Yamamoto, Hidetoshi Ito and Eriko Kinugasa

    Citation: Renal Replacement Therapy 2017 3:49

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  29. Content type: Case Report

    The authors herein report a case of paradoxical cerebral infarction by spraying thrombus in the catheter for dialysis. The clinical manifestations of paradoxical cerebral infarction are nonspecific, and the di...

    Authors: Seiji Hashimoto, Hiroyoshi Sasaki, Hiroshi Matsuura, Takao Koike and Tomoaki Haga

    Citation: Renal Replacement Therapy 2017 3:44

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  30. Content type: Research

    We evaluated the biocompatibility and small protein permeability of a newly developed hydrophilic-coated membrane dialyzer (NV) compared with conventional polysulfone dialyzer (APS) for hemodialysis (HD) therapy.

    Authors: Hirotoshi Kodama, Akira Tsuji, Akihiro Fujinoki, Koujirou Ooshima, Kaori Ishizeki and Tatsuo Inoue

    Citation: Renal Replacement Therapy 2017 3:40

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  31. Content type: Review

    Frailty is a clinical state in which there is an increase in the individual’s vulnerability to developing increased dependency and/or mortality when exposed to a stressor. Since the mean age of dialysis patien...

    Authors: Kosaku Nitta, Norio Hanafusa and Ken Tsuchiya

    Citation: Renal Replacement Therapy 2017 3:41

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  32. Content type: Case Report

    Okinoerabu Island and Tokunoshima Island lie in the sea to the south of the Japanese mainland, about 100 km north of Okinawa and about 500 km south of Kyushu. There are no facilities that specialize in kidney ...

    Authors: Hajime Hirano, Ryoichi Maenosono, Tomohisa Matsunaga, Hirofumi Uehara, Hayahito Nomi, Takuya Tsujino, Naoki Tanda, Kenkichi Saito, Taizo Uchimoto, Naokazu Ibuki, Teruo Inamoto, Yoshihiro Tokeshi and Haruhito Azuma

    Citation: Renal Replacement Therapy 2017 3:46

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  33. Content type: Research

    Pneumonia is common in hemodialysis (HD) patients and has a poor prognosis, but there is little information on an accurate method for evaluating the severity of pneumonia, which is closely associated with prog...

    Authors: Makoto Harada, Takeshi Masubuchi, Kazuaki Fujii, Yukifumi Kurasawa, Tohru Ichikawa and Mamoru Kobayashi

    Citation: Renal Replacement Therapy 2017 3:39

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  34. Content type: Research

    Ferric citrate hydrate (FCH), an iron-based phosphate binder, affects mineral and iron metabolism in patients with chronic kidney disease (CKD). The long-term impact of FCH on iron overload is unknown. With th...

    Authors: Maki Hiratsuka, Katsushi Koyama, Kinya Sengo, Jun Yamamoto, Aiko Narita, Chiharu Ito, Satoshi Kominato, Arata Hibi, Keisuke Kamiya, Rumi Miyahara, Junichi Fujikawa and Toshiyuki Miura

    Citation: Renal Replacement Therapy 2017 3:37

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  35. Content type: Research

    Iron-based phosphate binders are widely used in hemodialysis, to avoid the increased mortality associated with high serum phosphate in dialysis patients. However, comparative studies on the effects of phosphat...

    Authors: Takeo Ishii, Yukiko Nakajima and Kunio Oyama

    Citation: Renal Replacement Therapy 2017 3:38

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  36. Content type: Research

    Peritoneal dialysis peritonitis remains a significant cause of morbidity for peritoneal dialysis patients and the main reason for conversion from peritoneal dialysis to hemodialysis. As the characteristics of ...

    Authors: Vui Eng Phui, Clare Hui Hong Tan, Chee Kean Chen, Kee Hoe Lai, Kwek Foong Chew, Hock Hin Chua, Laura Lui Sian Ngu and Lawrence Wei Soon Hii

    Citation: Renal Replacement Therapy 2017 3:35

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  37. Content type: Research

    Newly formed membrane (NFM) on the peritoneal membrane proper is a unique pathological hallmark of encapsulating peritoneal sclerosis (EPS), but its definition and diagnostic significance have not been well de...

    Authors: Kazuho Honda, Chieko Hamada, Kunio Kawanishi, Masaaki Nakayama, Masanobu Miyazaki and Yasuhiko Ito

    Citation: Renal Replacement Therapy 2017 3:33

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  38. Content type: Research

    The production of presepsin has been shown to be strongly related to bacterial phagocytosis. The purpose of the present study is to compare the usefulness of presepsin for diagnosing localized skin wound infec...

    Authors: Jun Shiota, Hitoshi Tagawa, Norihiko Ohura and Hitoshi Kasahara

    Citation: Renal Replacement Therapy 2017 3:31

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  39. Content type: Research

    The Geriatric Nutritional Risk Index (GNRI) is a nutritional screening method primarily developed for elderly people; it is also reported to be useful for predicting mortality in patients on maintenance dialys...

    Authors: Akihito Tanaka, Daijo Inaguma, Hibiki Shinjo, Minako Murata and Asami Takeda

    Citation: Renal Replacement Therapy 2017 3:27

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  40. Content type: Research

    Hemodialysis with polymethylmetacrylate (PMMA) membrane dialyzers allows unique protein adsorption. New PMMA dialyzers should demonstrate equivalent protein adsorption, but improved hemocompatibility.

    Authors: Ikuto Masakane, Shiho Esashi, Asami Yoshida, Tetsuro Chida, Hiroaki Fujieda, Yoshiyuki Ueno and Hiroyuki Sugaya

    Citation: Renal Replacement Therapy 2017 3:32

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  41. Content type: Research

    Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is associated with high mortality in critically ill patients. However, the optimal timing to initiate CRRT in patients with AKI i...

    Authors: Jun Suzuki, Tetsu Ohnuma, Hidenori Sanayama, Kiyonori Ito, Takayuki Fujiwara, Hodaka Yamada, Alan Kawarai Lefor and Masamitsu Sanui

    Citation: Renal Replacement Therapy 2017 3:30

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  42. Content type: Review

    The number of older dialysis patients is increasing in many countries. For example, the trend is linked to the increase in the dialysis patients 70 years of age and over in Japan. Older dialysis patients often...

    Authors: Norio Hanafusa, Kosaku Nitta and Ken Tsuchiya

    Citation: Renal Replacement Therapy 2017 3:29

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  43. Content type: Research

    Although it is believed that chronic kidney disease (CKD) in patients with ischemic heart disease (IHD) negatively affects physical activity after discharge, its actual influence on the physical activity of pa...

    Authors: Ryota Matsuzawa, Takashi Masuda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Shinya Tanaka, Emi Maekawa and Junya Ako

    Citation: Renal Replacement Therapy 2017 3:28

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  44. Content type: Review

    Sepsis due to microbial invasion often causes multiple organ failure (MOF), including acute kidney injury (AKI), with high mortality rates in serious cases. Hence, there is an urgent need for diagnostic biomar...

    Authors: Eiichi Sato, Atsuko Kamijo-Ikemori, Tsuyoshi Oikawa, Aya Okuda, Takeshi Sugaya, Kenjiro Kimura, Tsukasa Nakamura and Yugo Shibagaki

    Citation: Renal Replacement Therapy 2017 3:26

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