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  1. Pemetrexed (PEM) is administered over a long term to patients with non-squamous cell lung cancer as a maintenance therapy after platinum combination induction chemotherapy. Although decreased renal function ow...

    Authors: Kengo Umehara, Kaori Yama, Nozomi Koike, Shintarou Takayama, Azusa Wakamoto, Tae Hatuyama, Michiya Kobayashi and Hideki Sato
    Citation: Renal Replacement Therapy 2020 6:43
    Content type: Research Published on:

  2. The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was sent to 4458 dialysis facilities at the end of 2018; among these facilities, 4402 facilities (98.7%) responded to t...

    Authors: Kosaku Nitta, Shunsuke Goto, Ikuto Masakane, Norio Hanafusa, Masatomo Taniguchi, Takeshi Hasegawa, Shigeru Nakai, Atsushi Wada, Takayuki Hamano, Junichi Hoshino, Nobuhiko Joki, Masanori Abe, Keiichi Yamamoto and Hidetomo Nakamoto
    Citation: Renal Replacement Therapy 2020 6:41
    Content type: Position statement Published on:

  3. Multiple factors including older age, comorbidities, inflammation, metabolic acidosis, dialysis-related hypercatabolism and anabolic resistance of skeletal muscle, extraction of circulating amino acids through...

    Authors: Ryota Matsuzawa, Shohei Yamamoto, Yuta Suzuki, Yoshifumi Abe, Manae Harada, Takahiro Shimoda, Keigo Imamura, Sachi Yamabe, Haruka Ito, Shun Yoshikoshi and Atsuhiko Matsunaga
    Citation: Renal Replacement Therapy 2020 6:40
    Content type: Research Published on:

  4. Protein-energy wasting (PEW) is a frequently observed complication that leads to increased mortality in hemodialysis patients. However, a multifaceted assessment of PEW by combined objective nutritional parame...

    Authors: Shunsuke Yamada, Toshiaki Nakano, Shoji Tsuneyoshi, Hokuto Arase, Sho Shimamoto, Masatomo Taniguchi, Masanori Tokumoto, Hideki Hirakata, Hiroaki Ooboshi, Kazuhiko Tsuruya and Takanari Kitazono
    Citation: Renal Replacement Therapy 2020 6:39
    Content type: Research Published on:

  5. Traditional vascular risk factors such as hypertension, diabetes mellitus, hyperlipidemia, cigarette smoking, and cardiovascular disease with myocardial infarction and atrial fibrillation have been linked to c...

    Authors: Yuta Noguchi, Marina Ito, Mai Mushika, Takuya Ito and Naoto Kawamura
    Citation: Renal Replacement Therapy 2020 6:38
    Content type: Research Published on:

  6. Dialysis membranes that release nitric oxide (NO) from their surface, mimicking one of the functions of endothelial cells, may suppress platelet reactivity during hemodialysis treatment. The aim of the present...

    Authors: Shunichiro Urabe, Kenichi Kokubo, Hiroshi Tsukao, Kozue Kobayashi, Minoru Hirose and Hirosuke Kobayashi
    Citation: Renal Replacement Therapy 2020 6:37
    Content type: Research Published on:

  7. Social frailty—the lack of a connection to society and infrequent social activities—has been reported to be associated with future declines in physical function in elderly individuals. This study aimed to eval...

    Authors: Koki Abe, Yoshinosuke Shimamura, Takuto Maeda, Yoshikazu Kato, Yasuyoshi Yoshimura, Tomomi Tanaka and Hideki Takizawa
    Citation: Renal Replacement Therapy 2020 6:36
    Content type: Research Published on:

  8. Polysulfone (PS) dialyzers are most frequently used worldwide for chronic renal failure patients and they are produced by several manufacturers. Despite using the same materials, differences in biocompatibilit...

    Authors: Mitsuru Kubo, Ryoichi Nakazawa, Kazuhiro Akiyama, Yoshiho Tsunoda, Kazumasa Kimura, Kenji Koide, Yasuhisa Matsushima, Shinji Hasegawa, Koichi Ikeda and Nakanobu Azuma
    Citation: Renal Replacement Therapy 2020 6:35
    Content type: Research Published on:

  9. Septic shock is a life-threatening condition and one of the most common causes of acute kidney injury (AKI). The acrylonitrile-co-methallyl sulfonate surface-treated (AN69ST) membrane used in severe sepsis was...

    Authors: Naoto Nishizaki, Riko Ueno, Yuki Nagayama, Hanako Abe, Akina Matsuda, Akira Mizutani, Kaoru Obinata, Tadaharu Okazaki and Toshiaki Shimizu
    Citation: Renal Replacement Therapy 2020 6:34
    Content type: Case Report Published on:

  10. To our knowledge, there are no preexisting reports concerning rilpivirine (RPV) removal by hemodialysis and peritoneal dialysis.

    Authors: Nanako Oshiro, Kentaro Kohagura, Shoji Tsuneyoshi, Masao Tateyama, Ryo Zamami, Hitoshi Uehara, Jiro Fujita and Yusuke Ohya
    Citation: Renal Replacement Therapy 2020 6:33
    Content type: Case Report Published on:

  11. Brain natriuretic peptide (BNP) levels are used as a marker of heart failure, which is the leading cause of morbidity and mortality in dialysis patients. BNP levels increase as renal function declines. The ran...

    Authors: Etsuko Kumagai, Keiko Hosohata, Kazuhiro Furumachi and Shinji Takai
    Citation: Renal Replacement Therapy 2020 6:32
    Content type: Research Published on:

  12. Delayed graft function (DGF) can affect short- and long-term allograft outcomes in kidney transplant recipients. One of the pathophysiological pathways in the occurrence of DGF is ischemia-reperfusion injury (...

    Authors: Mina Borran, Simin Dashti-Khavidaki, Azam Alamdari, Neda Naderi and Farzanehsadat Minoo
    Citation: Renal Replacement Therapy 2020 6:31
    Content type: Research Published on:

  13. Rhabdomyolysis may develop into acute kidney injury (AKI), a life-threatening complication. Obese people are at risk for rhabdomyolysis due to prolonged immobilization. However, there are only a few reports of...

    Authors: Kazuhiro Sakai, Hiroki Omizo, Ryo Togashi, Yuto Hayama, Masaki Ueno, Yoshihiro Tomomitsu, Yoshikazu Nemoto, Shinichiro Asakawa, Michito Nagura, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Shunya Uchida, Shigeru Shibata and Yoshihide Fujigaki
    Citation: Renal Replacement Therapy 2020 6:30
    Content type: Case Report Published on:

  14. Pembrolizumab, a highly selective humanized monoclonal IgG4κ isotype antibody against PD-1, is one of the immune checkpoint inhibitors approved for treatment of various cancers. The most frequent immune-relate...

    Authors: Manabu Hayata, Masaya Shimanuki, Takehiro Ko, Ryosuke Date, Ami Hamaguchi, Aki Tominaga, Rei Miura, Teruhiko Mizumoto and Masashi Mukoyama
    Citation: Renal Replacement Therapy 2020 6:29
    Content type: Case Report Published on:

  15. Endothelial dysfunction starts at an earlier stage in patients with chronic kidney disease (CKD), and induces macro- and microcirculatory impairments. We evaluated whether uremic toxin-lowering therapy could i...

    Authors: Takayasu Ohtake, Yasuhiro Mochida, Kunihiro Ishioka, Hidekazu Moriya, Sumi Hidaka, Masahiro Hirata, Hirokazu Yamada, Hiromichi Kumagai and Shuzo Kobayashi
    Citation: Renal Replacement Therapy 2020 6:28
    Content type: Research Published on:

  16. Arteriosclerosis may progress and lead to peripheral arterial disease (PAD) during the waiting period until kidney transplantation in end-stage kidney disease (ESKD) patients. Additionally, contrast-induced ne...

    Authors: Masataka Banshodani, Seiji Marubayashi, Sadanori Shintaku, Tomoyasu Sato, Misaki Moriishi, Shinichiro Tsuchiya, Hideki Ohdan and Hideki Kawanishi
    Citation: Renal Replacement Therapy 2020 6:27
    Content type: Case Report Published on:

  17. Carbamazepine-induced acute kidney injury is mainly caused by acute tubulointerstitial nephritis. Only one case of carbamazepine-induced eosinophilic granulomatosis with polyangiitis (EGPA) with acute kidney i...

    Authors: Tetsuya Abe, Keiko Nishiyama, Takuya Yamazaki, Ryoma Miyasaka, Yukari Honma, Hiroshi Tominaga, Keiko Hashimoto, Takanori Masaki, Fumi Kamata, Mariko Kamata, Togo Aoyama, Takashi Sano, Yasuo Takeuchi and Shokichi Naito
    Citation: Renal Replacement Therapy 2020 6:26
    Content type: Case Report Published on:

  19. Pleuroperitoneal communication is a potential complication of peritoneal dialysis (PD). Of the various treatment strategies for pleuroperitoneal communication, successful treatment with pleurodesis using autol...

    Authors: Satoru Tatematsu, Koji Hosoya and Munekazu Ryuzaki
    Citation: Renal Replacement Therapy 2020 6:24
    Content type: Case Report Published on:

  20. Peritonitis is a crucial complication that leads to hospitalization or even death in patients who are undergoing peritoneal dialysis (PD). The incidence of PD-related peritonitis associated with nontuberculous...

    Authors: Kohsuke Terada, Tomohiro Yan, Koji Mugishima, Sayuri Kawasaki, Fumiaki Itagaki, Takehisa Yamada and Yukinao Sakai
    Citation: Renal Replacement Therapy 2020 6:23
    Content type: Case Report Published on:

  21. Hemodialysis patients tend to be in “unstable psychological conditions” because of complications and physical activity restriction. This study aimed to investigate unusual psychological factors and their influ...

    Authors: Junko Takahashi, Takaya Abe, Mariko Kaneko, Nariyuki Sasaki, Yumiko Takasawa, Tetsuo Kato, Tomohiko Matsuura, Jun Sugimura, Kentaro Fukumoto, Kotaro Otsuka and Wataru Obara
    Citation: Renal Replacement Therapy 2020 6:22
    Content type: Research Published on:

  23. The application of presepsin for diagnosing infections in hemodialysis (HD) patients has not been confirmed yet. In addition, whether presepsin can detect atypical mycobacterial infection or not remains unknown.

    Authors: Jun Shiota
    Citation: Renal Replacement Therapy 2020 6:20
    Content type: Case Report Published on:

  24. Peritonitis is a common and clinically important complication in patients receiving peritoneal dialysis (PD). Antibiotic administration is essential for PD-related peritonitis, but routes of administration hav...

    Authors: Kohkichi Morimoto, Hiroyuki Terawaki, Naoki Washida, Takahiro Kasai, Yasushi Tsujimoto, Hidemichi Yuasa, Munekazu Ryuzaki, Yasuhiko Ito, Masashi Tomo and Hidetomo Nakamoto
    Citation: Renal Replacement Therapy 2020 6:19
    Content type: Review Published on:

  25. Neurological symptoms sometimes occur in hemodialysis patients, with causes including cerebral infarction, cerebral hemorrhaging, meningitis, and encephalitis. Dialysis disequilibrium syndrome (DDS) is widely ...

    Authors: Miki Uwatoko, Koki Tokunaga, Mako Kawano, Masahisa Kamimura, Yutaro Ibi, Masayuki Otsuka, Masato Minami, Haruhito Yoshimine, Fujio Hamada and Akio Ido
    Citation: Renal Replacement Therapy 2020 6:18
    Content type: Case Report Published on:

  26. The association of glycated albumin (GA) with mortality is unclear in chronic hemodialysis patients with diabetes. We investigated the usefulness of GA by comparing it with hemoglobin A1c (HbA1c) in this patie...

    Authors: Ko Hanai, Makoto Akamatsu, Aki Fujimori, Harumichi Higashi, Yumiko Horie, Yoshiaki Itaya, Minoru Ito, Tomoko Kanamaru, Hiroshi Kawaguchi, Kan Kikuchi, Hideo Kobayashi, Machiko Komatsu, Takao Kubota, Kenichi Kudo, Satoshi Kurihara, Ikuto Masakane…
    Citation: Renal Replacement Therapy 2020 6:17
    Content type: Research Published on:

  27. Septic shock is a life-threatening condition and one of the most common causes of acute kidney injury. Polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) is used to reduce endotoxin levels in ...

    Authors: Hisato Shima, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Shunji Hashizume, Nobuyuki Takamori, Megumi Harada, Yusuke Higashiguchi, Chiaki Masaki, Taro Banno, Naoki Nagasaka, Ayako Ito, Tomoko Inoue, Manabu Tashiro, Masaaki Nishitani, Kazuhiko Kawahara…
    Citation: Renal Replacement Therapy 2020 6:16
    Content type: Case Report Published on:

  28. Kidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can o...

    Authors: Alissar El Chediak, Khaled Janom and Sahar H. Koubar
    Citation: Renal Replacement Therapy 2020 6:15
    Content type: Review Published on:

  29. Catheter malfunction is one of the most important complications of peritoneal dialysis (PD). We have performed minilaparotomy for catheter repair by nephrologists. This study aimed to evaluate the effectivenes...

    Authors: Tsutomu Sakurada, Kaori Kohatsu, Shohei Yamada, Hirotaka Sato, Shigeki Kojima, Kenichiro Koitabashi, Nagayuki Kaneshiro and Yugo Shibagaki
    Citation: Renal Replacement Therapy 2020 6:14
    Content type: Case Report Published on:

  30. Septic pulmonary embolism (SPE) is an uncommon but serious complication resulting from infection of the blood. Gram-positive cocci, including methicillin-susceptible Staphylococcus aureus and methicillin-resistan...

    Authors: Hiroki Shimada, Mari Tanaka, Yohtaro Takami, Mariko Teragaki, Kotaro Maeda, Hirona Saita, Seira Nishikawa, Keisuke Taniguchi, Sachio Iwanari, Masaki Ikeda and Hiroya Takeoka
    Citation: Renal Replacement Therapy 2020 6:13
    Content type: Case Report Published on:

  31. The International Society for Peritoneal Dialysis guidelines recommends the topical application of antibiotics on the exit site for the prevention of peritoneal dialysis (PD)-related infections. However, the r...

    Authors: Yoko Obata, Miho Murashima, Naohiro Toda, Shuto Yamamoto, Yoshihiro Tsujimoto, Yasushi Tsujimoto, Hiraku Tsujimoto, Hidemichi Yuasa, Munekazu Ryuzaki, Yasuhiko Ito, Tadashi Tomo and Hidetomo Nakamoto
    Citation: Renal Replacement Therapy 2020 6:12
    Content type: Research Published on:

  32. The number of elderly patients (> 80 years of age) with end-stage renal disease is rapidly increasing. The initiation of dialysis extends the duration of survival; however, the rate of early mortality, that wh...

    Authors: Masaki Yoshida, Masanori Otsuka, Yoshikazu Watanabe, Takako Harigai, Noriyuki Sakurai, Keiko Kobatake, Hiroaki Yoshida, Satsuki Kobayashi, Takayuki Matsumoto, Tatsuhiko Sakamoto and Kazue Ueki
    Citation: Renal Replacement Therapy 2020 6:11
    Content type: Research Published on:

  33. Online hemodiafiltration (OHDF), which results in high albumin leakage, is now widely used in Japan for dialysis, since the national insurance system began reimbursing its costs in 2012. Glycated albumin (GA) ...

    Authors: Yukie Kitajima, Shunichiro Urabe, Takashi Hosono, Satoshi Yoshikawa, Yuzuru Sato and Toru Hyodo
    Citation: Renal Replacement Therapy 2020 6:10
    Content type: Research Published on:

  34. Familial juvenile hereditary nephropathy (FJHN) is characterized by hyperuricemia due to severely impaired urinary excretion of urate. Hereditary renal hypouricemia is an inborn error of membrane transport. Be...

    Authors: Fateme Shamekhi Amiri and Zohreh Rostami
    Citation: Renal Replacement Therapy 2020 6:9
    Content type: Review Published on:

  35. Prolonged peritoneal dialysis (PD) is responsible for progressive morphological changes such as deterioration of the peritoneal membrane. These changes increase the risk of encapsulating peritoneal sclerosis (...

    Authors: Tohru Mizumasa, Kazuho Honda, Shigehisa Aoki, Chieko Hamada, Masanobu Miyazaki, Yasuhiko Ito, Yudo Tanno, Toshiaki Nakano and Masaaki Nakayama
    Citation: Renal Replacement Therapy 2020 6:8
    Content type: Position statement Published on:

  36. Icodextrin enhances peritoneal filtration for patients on peritoneal dialysis (PD). However, clinically important outcomes have not yet been analyzed using authentic, objective statistical methods. The present...

    Authors: Atsuhiro Kanno, Yasushi Tsujimoto, Takayuki Fujii, Emi Fujikura, Kimio Watanabe, Hidemichi Yuasa, Munekazu Ryuzaki, Yasuhiko Ito and Hidetomo Nakamoto
    Citation: Renal Replacement Therapy 2020 6:7
    Content type: Review Published on:

  37. Living kidney transplantation comprises the majority of kidney transplantations in Japan. Living kidney donors should be assured of their own health. Therefore, Japanese guidelines define the criterion of kidn...

    Authors: Koji Hashimoto, Makoto Harada, Yosuke Yamada, Mitsutoshi Sugano, Tomonori Minagawa, Teruyuki Ogawa, Osamu Ishizuka and Yuji Kamijo
    Citation: Renal Replacement Therapy 2020 6:6
    Content type: Research Published on:

  39. This study investigated the association between the blood pressure response during hemodialysis (HD) and exercise tolerance or heart rate recovery (HRR) measured with cardiopulmonary exercise testing (CPX).

    Authors: Hiroki Yabe, Kenichi Kono, Ryota Shiraki, Akiho Masuda, Yoshifumi Moriyama and Hirotake Kasuga
    Citation: Renal Replacement Therapy 2020 6:4
    Content type: Research Published on:

  40. Catheter-related infection of peritoneal dialysis (PD) is one of the serious factors of peritonitis. However, an antibacterial PD catheter has not been commercially available in Japan yet. From an infection co...

    Authors: Hiroki Gyotoku, Yoshinano Azuma and Tsutomu Furuzono
    Citation: Renal Replacement Therapy 2020 6:3
    Content type: Research Published on:

  41. Haemodialysis (HD) patients may suffer symptoms during dialysis and take time to recover post HD. We wished to determine whether patients with symptomatic intra-dialytic hypotension (IDH), requiring nursing in...

    Authors: Suree Yoowannakul, Surachet Vongsanim, Kamonwan Tangvoraphonkchai, Ahmed Mohamed and Andrew Davenport
    Citation: Renal Replacement Therapy 2020 6:2
    Content type: Research Published on:

  43. The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was conducted for 4413 dialysis facilities at the end of 2017; among which 4360 facilities (98.8%) responded to the fac...

    Authors: Kosaku Nitta, Ikuto Masakane, Norio Hanafusa, Masatomo Taniguchi, Takeshi Hasegawa, Shigeru Nakai, Shunsuke Goto, Atsushi Wada, Takayuki Hamano, Junichi Hoshino, Nobuhiko Joki, Masaki Abe, Keichi Yamamoto and Hidetomo Nakamoto
    Citation: Renal Replacement Therapy 2019 5:53
    Content type: Position statement Published on:

  44. Transcatheter aortic valve implantation (TAVI) has evolved to be a treatment of choice in high-risk patients with aortic stenosis (AS). However, it is not known whether TAVI is safe and beneficial for the crea...

    Authors: Minoru Yasukawa, Hiroki Omizo, Kazuhiro Sakai, Sachiko Kitagawa, Takahiro Kikuyama, Masaki Yamanaka, Fumika Ochiai, Ryo Togashi, Yoshikazu Nemoto, Tatsuya Ota, Hideyuki Kawashima, Shintaro Takamura, Yusuke Watanabe, Ken Kozuma, Shigeru Shibata and Yoshihide Fujigaki
    Citation: Renal Replacement Therapy 2019 5:52
    Content type: Case Report Published on:

  45. Constipation is highly prevalent in patients with chronic kidney disease (CKD) and is primarily characterized by decreased intestinal motility. This chronic disorder affects the quality of life of patients. Ho...

    Authors: Ryota Ikee, Kazuhiro Yano and Tomomi Tsuru
    Citation: Renal Replacement Therapy 2019 5:51
    Content type: Review Published on:

  46. Elderly adults undergoing hemodialysis (HD) have multiple comorbidities, physical frailty, and functional dependence with activities of daily living (ADL). ADL difficulty is an early predictor of ADL dependenc...

    Authors: Toshiki Kutsuna, Yusuke Isobe, Takaaki Watanabe, Yusuke Matsunaga, Satomi Kusaka, Yasuaki Kusumoto, Junko Tsuchiya, Masaru Umeda, Hiroyuki Watanabe, Shinobu Shimizu, Atsushi Yoshida and Atsuhiko Matsunaga
    Citation: Renal Replacement Therapy 2019 5:50
    Content type: Research Published on:

  48. Thrombotic microangiopathy (TMA) in patients with connective tissue disease is rare but life-threatening. In particular, the survival rate of patients with dermatomyositis (DM) that develop TMA is low. The eff...

    Authors: Norifumi Hayashi, Keiichirou Okada, Yuko Tsuruyama, Yu Kagaya, Sho Kumano, Yuki Ishikura, Kiminobu Takeda, Masayuki Nanbu, Keiji Fujimoto, Hiroki Adachi and Hitoshi Yokoyama
    Citation: Renal Replacement Therapy 2019 5:48
    Content type: Case Report Published on:

  49. Higher serum uric acid (UA) levels are associated with poorer renal prognosis. In kidney transplantation, both donors and recipients are diagnosed as having chronic kidney diseases (CKD) based on renal functio...

    Authors: Mineaki Kitamura, Yasushi Mochizuki, Tsuyoshi Matsuda, Yuta Mukae, Hiromi Nakanishi, Yuki Ota, Tadashi Uramatsu, Yoko Obata, Hideki Sakai, Hiroshi Mukae and Tomoya Nishino
    Citation: Renal Replacement Therapy 2019 5:47
    Content type: Research Published on:

  50. Diabetes mellitus is the leading cause of end-stage renal disease. Monitoring and controlling normal blood sugar levels play a critical role in slowing the progression of micro- and macrovascular complications...

    Authors: Mohammad K. Hemadneh, Sohaib T. Khatib, Samer A. Hasan, Ihab N. Tahboub, Emad Khazneh and Sa’ed H. Zyoud
    Citation: Renal Replacement Therapy 2019 5:45
    Content type: Research Published on:
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Renal Replacement Therapy

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